Hsc70 Cancer Research Results

Hsc70, Heat Shock Cognate Protein 70: Click to Expand ⟱
Source:
Type:
Hsc70 is critical for cancer cell survival. HSC70 shares some of the structural and functional similarity with HSP70. HSC70 also has different properties compared with HSP70 and other heat shock family members. HSC70 performs its full functions by the cooperation of co-chaperones. It interacts with many other molecules as well and regulates various cellular functions.
Scientific Papers found: Click to Expand⟱
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Figure 3b shows that quercetin treatment caused a dose-dependent augmentation in mRNA levels of Diablo and FAS
Diablo↑,
Fas↓,
Hsc70↓, coupled with a dose-responsive reduction in transcriptional activity of HSC70, HIF1A, Mcl-1, Hsp90 and BIRC4.
Hif1a↓,
Mcl-1↓,
HSP90↓,
FLT4↓, A dose-dependent drop in mRNA levels of FLT4, EPHB4, DNAPK, PARP1, ATM, perlecan, GnTV and heparanase genes was observed after treatment of PC-3 cells with quercetin
EphB4↓,
DNA-PK↓,
PARP1↓,
ATM↓,
XIAP↝,
PLC↓,
GnT-V↝,
heparanase↝,
NM23↑, quercetin significantly exerted a dose-responsive rise in transcriptional levels of NM23 and CSR1 genes
CSR1↑,
SPP1↓, coupled with an expressive lowering in mRNA levels of SPP1, DNMT1, HDAC4, CXCR4, b-catenin and NHE1.
DNMT1↓,
HDAC4↓,
CXCR4↓,
β-catenin/ZEB1↓,
FBXW7↝,
AMACR↓,
cycD1/CCND1↓,
IGF-1R↓, down-regulation of mRNA levels of AMACR, cyclin D1, NOS2A, IGF1R, IMPDH1, IMPDH2 and HEC1
IMPDH1↓,
IMPDH2↓,
HEC1↓,
NHE1↓,
NOS2↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↓, 1,  

Cell Death ⓘ

aSmase↝, 1,   CSR1↑, 1,   Diablo↑, 1,   Fas↓, 1,   Mcl-1↓, 1,  

Transcription & Epigenetics ⓘ

SPP1↓, 1,  

Protein Folding & ER Stress ⓘ

Hsc70↓, 1,   HSP90↓, 1,  

DNA Damage & Repair ⓘ

ATM↓, 1,   DNA-PK↓, 1,   DNMT1↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

FBXW7↝, 1,   HDAC4↓, 1,   IGF-1R↓, 1,  

Migration ⓘ

EphB4↓, 1,   GnT-V↝, 1,   heparanase↝, 1,   NM23↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

FLT4↓, 1,   Hif1a↓, 1,  

Barriers & Transport ⓘ

NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↓, 1,  

Cellular Microenvironment ⓘ

PLC↓, 1,  

Clinical Biomarkers ⓘ

HEC1↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

IMPDH1↓, 1,   IMPDH2↓, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Hsc70, Heat Shock Cognate Protein 70
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:473  State#:%  Dir#:1
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