LC3s Cancer Research Results

LC3s, Autophagosome Proteins: Click to Expand ⟱
Source:
Type:
LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Whether these three LC3 proteins have a similar biological role in autophagy remains obscure.
Protumorigenic: In many cases, especially in advanced cancers, increased autophagy (reflected by high LC3 levels) can support tumor growth by providing nutrients and promoting cell survival under stress conditions.
Antitumorigenic: Conversely, in early-stage tumors or in response to certain therapies, autophagy can act as a tumor suppressor by preventing the accumulation of damaged organelles and proteins.
Scientific Papers found: Click to Expand⟱
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,
4729- Se,    Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilers
*ROS↓, *NRF2↑, *GPx1↑, *NQO1↑, *mTOR↑, *Beclin-1↓, *ATG5↓, *LC3s↓, *hepatoP↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,   ROS↑, 2,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PDKs↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   Cyt‑c↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

LC3s↓, 1,   p62↑, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   mTOR↓, 1,   TumCG↓, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 3,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

Ferritin↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,   toxicity↝, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GPx1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↓, 1,   Beclin-1↓, 1,   LC3s↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↑, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: LC3s, Autophagosome Proteins
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:492  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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