FOXO Cancer Research Results

FOXO, Forkhead box O: Click to Expand ⟱
Source:
Type:
FOXO (Forkhead box O) refers to a family of transcription factors that play a crucial role in various cellular processes, including cell cycle regulation, apoptosis (programmed cell death), and stress resistance. The FOXO proteins, particularly FOXO1, FOXO3, FOXO4, and FOXO6, are involved in the regulation of genes that control these processes.
FOXO proteins can act as tumor suppressors. They promote apoptosis and inhibit cell proliferation, which can help prevent the development and progression of tumors. When FOXO is activated, it can lead to the expression of genes that induce cell cycle arrest and apoptosis, thereby inhibiting cancer cell growth.
FOXO proteins are regulated by phosphorylation through pathways such as the PI3K/Akt pathway. When Akt is activated, it phosphorylates FOXO, leading to its exclusion from the nucleus and subsequent degradation.
Scientific Papers found: Click to Expand⟱
171- Api,    Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
- Review, Var, NA
PI3K/Akt↓, NF-kB↓, CK2↓, FOXO↓, MAPK↝, ERK↓, p‑JAK↓, Wnt/(β-catenin)↓, ROS↑, CDC25↓, p‑STAT↓, DNAdam↑,
643- EGCG,    New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
- Analysis, NA, NA
H2O2↑, Fenton↑, PDGFR-BB↑, EGFR↓, VEGFR2↓, IGFR↓, Ca+2↑, NO↑, Sp1/3/4↓, NF-kB↓, AP-1↓, STAT1↓, STAT3↓, FOXO↓, mtDam↑, TumAuto↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   H2O2↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

PI3K/Akt↓, 1,  

Cell Death ⓘ

CK2↓, 1,   MAPK↝, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   FOXO↓, 2,   IGFR↓, 1,   p‑STAT↓, 1,   STAT1↓, 1,   STAT3↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   NO↑, 1,   PDGFR-BB↑, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

p‑JAK↓, 1,   NF-kB↓, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FOXO, Forkhead box O
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:525  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page