NEDD9 Cancer Research Results

NEDD9, Neural precursor cell expressed developmentally down-regulated protein 9: Click to Expand ⟱
Source:
Type:
NEDD9 (Neural Precursor Cell Expressed Developmentally Downregulated 9) is a protein that has been implicated in various cellular processes, including cell adhesion, migration, and signaling. It is part of the CAS (Crk-associated substrate) family of proteins and is known to interact with several signaling pathways, particularly those involving integrins and growth factor receptors.
NEDD9 is often found to be overexpressed in various types of cancers, including breast, lung, and colorectal cancers. This overexpression is associated with more aggressive tumor behavior and poorer prognosis.
NEDD9 interacts with several signaling pathways, including those mediated by epidermal growth factor receptor (EGFR) and other receptor tyrosine kinases. These interactions can enhance signaling pathways that promote cell survival, proliferation, and migration.
Scientific Papers found: Click to Expand⟱
174- Api,    Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, DLD1
NEDD9↓, Inhibition of apigenin on cell migration, invasion, and metastasis through downregulation of NEDD9 in vitro and in vivo
TumCMig↓, Apigenin attenuates NEDD9 expression, resulting in inhibition on cell migration, invasion, and metastasis of those cells.
TumCI↓,

476- CUR,    The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
- in-vitro, PC, PATU-8988 - in-vitro, PC, PANC1
TumCMig↓,
TumCI↓,
Apoptosis↑,
NEDD9↓,
p‑Akt↓,
p‑mTOR↓,
PTEN↑,
p73↑,
β-TRCP↑,

480- CUR,    Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells
- in-vitro, GBM, SNB19
TumCP↓,
TumCMig↓,
Apoptosis↑,
TumCCA↑, G2/M phase
NEDD9↓,
NOTCH1↓,
p‑Akt↓,

1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, suppresses the growth of BC cells by arresting the cell cycle in the G0/G1 phase,
TumCMig↓, suppresses migration, invasion, and metastatic
TumCI↓,
TumMeta↓,
Apoptosis↑, stimulates apoptosis in MCF-7 cells via TGF-β/Smad3 signaling axis
TGF-β↓,
SMAD3↓,
CDK6↓, inhibits CDK6 that is important in cell cycle regulation,
PI3K↓, inhibits the PI3K/AKT pathway
Akt↓,
angioG↓,
VEGFR2↓, reduces VEGFR-2 tyrosine kinase activity
MAPK↓,
NEDD9↓, downregulated protein 9 (NEDD-9)
NF-kB↓, EA suppressed NF-κB precursor protein p105
eff↑, They showed that the encapsulation of EA in biodegradable polymeric nanoparticles would improve the bioavailability after oral administration and also enhance the anticancer properties
eff↑, Chitosan nanoparticles and EA with high anticancer efficacy could be a suitable therapeutic strategy
RadioS↑, showed that the synergistic effect of EA combined with radiotherapy/chemotherapy resulted in increased DNA damage and apoptosis as well as decreased levels of MGMT expression
ChemoSen↑,
DNAdam↑,
eff↑, combination of Paclitaxel and EA has shown promise in inhibiting tumor growth and metastasis in experimental BC models.
*toxicity∅, 630 mg/kg is the LD50 of EA in the rat population.
*toxicity∅, no-observed adverse effect level of EA is 2000 mg/kg body weight


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↑, 3,   MAPK↓, 1,   β-TRCP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   p73↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

p‑mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Migration ⓘ

NEDD9↓, 4,   SMAD3↓, 1,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 3,   RadioS↑, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 2,  
Total Targets: 1

Scientific Paper Hit Count for: NEDD9, Neural precursor cell expressed developmentally down-regulated protein 9
2 Curcumin
1 Apigenin (mainly Parsley)
1 Ellagic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:527  State#:%  Dir#:1
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