TREM-1 Cancer Research Results

TREM-1, triggering receptor expressed on myeloid cells-1: Click to Expand ⟱
Source:
Type:
TREM1 promotes tumor progression, immunosuppression, and resistance to therapy by activating tumor-infiltrating myeloid cells.
sTREM-1 Serum soluble triggering receptor expressed on myeloid cells-1.
High levels of sTREM-1 were observed in 50% of breast cancer, 33.3% of Small Cell Lung carcinoma (SCLC), 26.7% of colorectal cancer and 13.3% of Non Small Cell Lung Carcinoma (NSCLC) patients.
Scientific Papers found: Click to Expand⟱
190- MFrot,  MF,  Chemo,    The efficacy and safety of low-frequency rotating static magnetic field therapy combined with chemotherapy on advanced lung cancer patients: a randomized, double-blinded, controlled clinical trial
- Human, Lung, NA
*IP-10/CXCL-10↑, MF group patients had higher concentrations of IP-10 and GM-CSF, and lower concentration of sTREM-1 in plasma
*GM-CSF↑, in PLASMA
*TREM-1↓, sTREM-1, in PLASMA
QoL↑, Comparing to CON group, more patients in MF group (66.7% vs 25.9%) were experiencing life quality improvement on day 21. significantly higher increase of FACT-L,TOI and LCS scores
Ca+2↑, MF treated cells were found to have higher intracellular Ca2+ concentration and Reactive Oxygen Species (ROS) reaction level, which led to higher apoptosis rates(Zhang et al. 2010;
ROS↑,
Apoptosis↑,
OS↑, median survival time for MF group and CON group was 6.7 months and 6.07 month respectively


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Migration ⓘ

Ca+2↑, 1,  

Functional Outcomes ⓘ

OS↑, 1,   QoL↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics ⓘ

TREM-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

GM-CSF↑, 1,   IP-10/CXCL-10↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: TREM-1, triggering receptor expressed on myeloid cells-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:536  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page