IL23 Cancer Research Results
IL23, Interleukin 23: Click to Expand ⟱
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A heterodimeric cytokine composed of an IL-12B subunit and an IL-23A subunit. IL-23 is part of the IL-12 family of cytokines.
IL-23 is an inflammatory cytokine. IL-23 is overexpressed in a number of cancer types.
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Scientific Papers found: Click to Expand⟱
*antiOx↑, Curcumin, a natural compound with potent antioxidant and anti-inflammatory properties
*Inflam↓,
*AntiAge↑, Its potential anti-aging properties are due to its power to alter the levels of proteins associated with senescence, such as adenosine 5′-monophosphate-activated protein kinase (AMPK) and sirtuins
*AMPK↑,
*SIRT1↑,
*NF-kB↓, preventing pro-aging proteins, such as nuclear factor-kappa-B (NF-κB) and mammalian target of rapamycin (mTOR)
*mTOR↓,
*NLRP3↓, Moreover, curcumin, by inhibiting the NF-κB pathway, can directly restrain the assembly or even inhibit the activation of the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome
*NADPH↓, by inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and elevating the activity of antioxidant enzymes and consequently lowering reactive oxygen species (ROS)
*ROS↓,
*COX2↓, (COX-2), granulocyte colony-stimulating factor (G-CSF), and monocyte chemotactic protein-1 (MCP-1) can be decreased by curcumin
*MCP1↓,
*IL1β↓, by decreasing IL-1β, IL-17, IL-23, TNF-α, and myeloperoxidase, enhancing levels of IL-10, and downregulating activation of NF-κB
*IL17↓,
*IL23↓,
*TNF-α↓,
*MPO↓,
*IL10↑,
*lipid-P↓, curcumin showed a significant decline in lipid peroxidation and increased superoxide dismutase levels, in addition to a reduction in Aβ aggregation and tau hyperphosphorylation through the regulation of GSK3β, Cdk5, p35, and p25
*SOD↑,
*Aβ↓,
*p‑tau↓,
*GSK‐3β↓,
*CDK5↓,
*TXNIP↓, Curcumin also has an inhibitory role on the thioredoxin-interacting protein (TXNIP)/NLRP3 inflammasome pathway
*NRF2↑, well as upregulation of Nrf2, NAD(P)H quinine oxidoreductase 1 (NQO1), HO-1, and γ-glutamyl cysteine synthetase (γ-GCS) in brain cells.
*NQO1↑,
*HO-1↑,
*OS↑, significant improvement in OS, and a positive evolution in memory and spatial learning
*memory↑,
*BDNF↑, Besides that, it promoted neurogenesis through increasing brain-derived neurotrophic factor (BDNF) levels
*neuroP↑, Curcumin can promote neuroprotection
*BACE↓, Figure 7
*AChE↓, figure 7
*LDL↓, and reduced total cholesterol and LDL levels.
*antiOx↑, shows potent antioxidant, antimicrobial, and immunoregulatory activities
*OS↑, JUG treatment significantly ameliorated body weight loss and disease activity index and improved the survival probability, colon length, and tissue damage.
*IL6↓, JUG reversed the DSS-induced up-regulation of proinflammatory cytokines, including interleukin (IL)-6, 12, 21, and 23, and tumor necrosis factor-alpha, and anti-inflammatory cytokines, such as IL-10 and transforming growth factor-beta,
*IL12↓,
*IL23↓,
*TNF-α↓,
*Inflam↓,
*NF-kB↓, the activation of mitochondrial uncoupling protein 2 and phospho-Nuclear Factor-kappa B p65 and the inhibition of the kelch-like ECH-associated protein 1 and NF-E2-related factor 2 induced by DSS were also reversed under JUG administration.
*NFE2L2↓,
*ROS↓, JUG could be a promising agent for UC prevention to regulate inflammatory cytokines and oxidative stress.
BMD↑, loss reduced
Cartilage↑, more intact cartilage surfaces and denser proteoglycan
IL17↓,
IL22↓,
IL23↓,
IL28↓,
CD4+↓, tremendously attenuated
CD8+↓, In this investigation, data showed that RMF treatment decreased CD3-expressing proliferative cells via immunostaining and reduced CD4+/CD8+ T-cells via flow cytometry in AS mice
LAMB3↑,
COL4↓,
THBS2↓,
ITGA11↓,
PPARγ↑, mice have decreased expression of peroxisome proliferator-activated receptor γ (PPAR-γ), a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily, which RMF reverses.
ACAA1↓,
PLIN1↓,
FABP4↓,
PCK1↓,
UCP1↓,
TNF-α↓,
Showing Research Papers: 1 to 3 of 3
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3
Pathway results for Effect on Cancer / Diseased Cells:
Mitochondria & Bioenergetics ⓘ
UCP1↓, 1,
Core Metabolism/Glycolysis ⓘ
ACAA1↓, 1, FABP4↓, 1, PCK1↓, 1, PLIN1↓, 1, PPARγ↑, 1,
Migration ⓘ
Cartilage↑, 1, COL4↓, 1, ITGA11↓, 1, LAMB3↑, 1, THBS2↓, 1,
Immune & Inflammatory Signaling ⓘ
CD4+↓, 1, IL17↓, 1, IL22↓, 1, IL23↓, 1, IL28↓, 1, TNF-α↓, 1,
Clinical Biomarkers ⓘ
BMD↑, 1,
Infection & Microbiome ⓘ
CD8+↓, 1,
Total Targets: 19
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 2, HO-1↑, 1, lipid-P↓, 1, MPO↓, 1, NFE2L2↓, 1, NQO1↑, 1, NRF2↑, 1, ROS↓, 2, SOD↑, 1,
Core Metabolism/Glycolysis ⓘ
AMPK↑, 1, LDL↓, 1, NADPH↓, 1, SIRT1↑, 1,
Proliferation, Differentiation & Cell State ⓘ
GSK‐3β↓, 1, mTOR↓, 1,
Migration ⓘ
CDK5↓, 1, TXNIP↓, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 1, IL10↑, 1, IL12↓, 1, IL17↓, 1, IL1β↓, 1, IL23↓, 2, IL6↓, 1, Inflam↓, 2, MCP1↓, 1, NF-kB↓, 2, TNF-α↓, 2,
Synaptic & Neurotransmission ⓘ
AChE↓, 1, BDNF↑, 1, p‑tau↓, 1,
Protein Aggregation ⓘ
Aβ↓, 1, BACE↓, 1, NLRP3↓, 1,
Clinical Biomarkers ⓘ
IL6↓, 1,
Functional Outcomes ⓘ
AntiAge↑, 1, memory↑, 1, neuroP↑, 1, OS↑, 2,
Total Targets: 39
Scientific Paper Hit Count for: IL23, Interleukin 23
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:543 State#:% Dir#:1
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