COL4 Cancer Research Results

COL4, Collagen IV alpha chain: Click to Expand ⟱
Source:
Type:
Family is a major component of the basement membrane (BM) that has recently been found to be involved in tumor angiogenesis and progression.
Type IV collagen, an important component of the basement membrane, is highly expressed by pancreatic cancer cells both in vivo and in vitro. The interaction between type IV collagen produced by the cancer cell, and integrins on the surface of the cancer cells, are important for continuous cancer cell growth, maintenance of a migratory phenotype, and for avoiding apoptosis.


Scientific Papers found: Click to Expand⟱
1104- CAR,    Carvacrol Ameliorates Transforming Growth Factor-β1-Induced Extracellular Matrix Deposition and Reduces Epithelial-Mesenchymal Transition by Regulating The Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway In Hk-2 Cells
- in-vitro, Kidney, HK-2
tumCV↓,
COL4↓,
COL1↓,
Fibronectin↓,
E-cadherin↑, attenuated (TGF-β1-induced) decrease of E-cadherin
Snail↑,
Vim↑,
α-SMA↑,
PI3K↓,
Akt↓,

193- MFrot,  MF,    Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions
- in-vivo, Arthritis, NA
BMD↑, loss reduced
Cartilage↑, more intact cartilage surfaces and denser proteoglycan
IL17↓,
IL22↓,
IL23↓,
IL28↓,
CD4+↓, tremendously attenuated
CD8+↓, In this investigation, data showed that RMF treatment decreased CD3-expressing proliferative cells via immunostaining and reduced CD4+/CD8+ T-cells via flow cytometry in AS mice
LAMB3↑,
COL4↓,
THBS2↓,
ITGA11↓,
PPARγ↑, mice have decreased expression of peroxisome proliferator-activated receptor γ (PPAR-γ), a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily, which RMF reverses.
ACAA1↓,
PLIN1↓,
FABP4↓,
PCK1↓,
UCP1↓,
TNF-α↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

UCP1↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACAA1↓, 1,   FABP4↓, 1,   PCK1↓, 1,   PLIN1↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,  

Migration ⓘ

Cartilage↑, 1,   COL1↓, 1,   COL4↓, 2,   E-cadherin↑, 1,   Fibronectin↓, 1,   ITGA11↓, 1,   LAMB3↑, 1,   Snail↑, 1,   THBS2↓, 1,   Vim↑, 1,   α-SMA↑, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   IL17↓, 1,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  

Infection & Microbiome ⓘ

CD8+↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: COL4, Collagen IV alpha chain
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:546  State#:%  Dir#:1
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