FABP4 Cancer Research Results

FABP4, Fatty acid-binding proteins 4: Click to Expand ⟱
Source:
Type:
Belongs to a family of intracellular lipid-binding protein, can bind hydrophobic ligands to regulate lipid trafficking and metabolism.
Has been found to be upregulated in many malignant solid tumors, and correlated with poor prognosis.
Scientific Papers found: Click to Expand⟱
3521- Bor,    A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway
- in-vitro, Obesity, 3T3
*CEBPA↓, Figure 2
*PPARγ↓,
*FASN↓,
*SREBP1↓,
*FABP4↓,
*GLUT4↓,
*β-catenin/ZEB1↑, Boron Activated the β-Catenin Signaling Pathway
*MMP2↓, As shown in Fig. 6, soluble transforming growth factor receptor 1 (sTNFR1) and matrix metalloproteinase 2 (MMP2) protein levels decreased in the presence of boron
*FGF↑, whereas basic fibroblast growth factor expression (bFGF) increased
*Ca+2?, Boric acid has been reported to interact with NAD + and inhibit cyclic ADP ribose-activated Ca 2+ release from ryanodine receptor, leading to decreased endoplasmic reticulum luminal Ca 2+ concentrations

193- MFrot,  MF,    Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions
- in-vivo, Arthritis, NA
BMD↑, loss reduced
Cartilage↑, more intact cartilage surfaces and denser proteoglycan
IL17↓,
IL22↓,
IL23↓,
IL28↓,
CD4+↓, tremendously attenuated
CD8+↓, In this investigation, data showed that RMF treatment decreased CD3-expressing proliferative cells via immunostaining and reduced CD4+/CD8+ T-cells via flow cytometry in AS mice
LAMB3↑,
COL4↓,
THBS2↓,
ITGA11↓,
PPARγ↑, mice have decreased expression of peroxisome proliferator-activated receptor γ (PPAR-γ), a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily, which RMF reverses.
ACAA1↓,
PLIN1↓,
FABP4↓,
PCK1↓,
UCP1↓,
TNF-α↓,

218- MFrot,  MF,    Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells
- in-vitro, Nor, NA
*PPARγ↓, PPARg2
*p‑JNK↑, p-JNK
*Wnt↑,
*ALP∅, ELF-MF had no effects on the expression of ALP, COL1a1, Runx2, and OCN
*COL1∅,
*RUNX2∅,
*OCN∅,
*FABP4↓, ELF-MF exposure for 15 days resulted in a decrease in PPARg2 and FABP4
*p‑JNK↑, p-JNK was increased after ELF-MF exposure
*Diff↓, adipogenic differentiation of MSCs could be inhibited by ELF-MF of 7.5 Hz, 0.4 T, suggesting the inhibitory effect of ELF-MF on obesity may be attributed to the inhibition of differentiation of MSCs into adipocytes.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

UCP1↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACAA1↓, 1,   FABP4↓, 1,   PCK1↓, 1,   PLIN1↓, 1,   PPARγ↑, 1,  

Migration ⓘ

Cartilage↑, 1,   COL4↓, 1,   ITGA11↓, 1,   LAMB3↑, 1,   THBS2↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   IL17↓, 1,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  

Infection & Microbiome ⓘ

CD8+↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

FABP4↓, 2,   FASN↓, 1,   PPARγ↓, 2,   SREBP1↓, 1,  

Cell Death ⓘ

p‑JNK↑, 2,  

Kinase & Signal Transduction ⓘ

OCN∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

CEBPA↓, 1,   Diff↓, 1,   FGF↑, 1,   RUNX2∅, 1,   Wnt↑, 1,  

Migration ⓘ

Ca+2?, 1,   COL1∅, 1,   MMP2↓, 1,   β-catenin/ZEB1↑, 1,  

Barriers & Transport ⓘ

GLUT4↓, 1,  

Clinical Biomarkers ⓘ

ALP∅, 1,  
Total Targets: 17

Scientific Paper Hit Count for: FABP4, Fatty acid-binding proteins 4
2 Magnetic Field Rotating
2 Magnetic Fields
1 Boron
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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