ALAT Cancer Research Results

ALAT, ALT, alanine aminotransferase: Click to Expand ⟱
Source:
Type: enzyme
(or ALT) -Used to be called serum glutamic-pyruvic transaminase (SGPT)
Most common in the liver.
An enzyme your body needs to break down proteins into energy.
It plays a crucial role in amino acid metabolism and is often measured in blood tests to assess liver function.
The catabolism of alanine by alanine aminotransferase 2 (ALT2) to pyruvate, was critical for the survival of non-small cell lung carcinoma (NSCLC) cells during glucose starvation. After knockdown of ALT2, cells were significantly more sensitive to glucose withdrawal compared to wildtype cells, which were rescued when supplemented with pyruvate.
Alanine aminotransferase (ALT) expression is highly elevated in the serum of patients with hepatocellular carcinoma.
A common example of dietary cancer therapy is the ketogenic diet, providing a fat-rich, low carbohydrate diet. The rationale is to reduce circulating glucose levels and induce ketosis.
Used as a clinical biomarker for Liver function.


Scientific Papers found: Click to Expand⟱
4390- AgNPs,    Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats
- in-vivo, Liver, NA
hepatoP↑, AST↓, ALAT↓, ALP↓,
4385- AgNPs,    Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice
- in-vitro, Liver, NA
hepatoP↑, *AST↓, *ALAT↓, *Catalase↑, *GPx↑, *GSTA1↑, *SOD↑,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
3446- ALA,  CUR,    The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
- in-vivo, Nor, NA
*hepatoP↑, *α-SMA↓, *COL3A1↓, *ROS↓, *GSH↑, *ALAT↓, *AST↓, *ALP↓, *MDA↓,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
5506- Ba,    Improved Bioavailability and Hepatoprotective Activity of Baicalein Via a Self-assembled Solutol HS15 Micelles System
- in-vivo, Nor, NA
*AST↓, *ALAT↓, *GSH↓, *SOD↓, *MDA↓, *hepatoP↑, *Inflam↓, BioAv↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1↓, MMP9↓, COX2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
5755- CA,    Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture
- Review, Nor, NA
*Imm↑, *Inflam↓, *Bacteria↓, *eff↑, *ROS↓, *MDA↓, *Catalase↑, *GSH↑, *TAC↑, *NF-kB↓, *NLRP3↓, *eff↑, *AST↓, *ALAT↓, *SOD↑, *GSTA1↑,
5924- CA,    Carnosic acid impedes cell growth and enhances anticancer effects of carmustine and lomustine in melanoma
- vitro+vivo, Melanoma, B16-F10
TumCG↓, TumCCA↑, P21↑, eff↑, AST↓, ALAT↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2↓, *MDA↓,
5909- CAR,    Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
*AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *GSR↑, *hepatoP↑, *lipid-P↓,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2↑, *NF-kB↓, *ICAM-1↓, *MCP1↓, *HO-1↑, CXCc↓,
3707- dietSTF,    Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats
- in-vivo, AD, NA
*memory↑, *Aβ↓, *AST↓, *ALAT↓,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
4022- FulvicA,  Chemo,    Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats
- in-vivo, OS, NA
AST↓, ALAT↓, ALP↓, Bil↝, creat↓, uricA↓, ChemoSen↑, chemoP↑,
2525- H2,    Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
- in-vivo, NA, NA
OS↓, cardioP↑, *AST↓, ALAT↓, *ROS↓, *MDA↓, *hepatoP↑, *Inflam↓, chemoP↑,
2524- H2,    Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
- Trial, NA, NA
hepatoP↑, ALAT↓, AST↓, Dose↝, Dose↝,
4238- HNK,    Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
- Review, AD, NA - NA, Park, NA
*BDNF↑, *hepatoP↑, *ALAT↓, *AST↓, *TNF-α↓, *SIRT3↑, *Aβ↓, *Apoptosis↓, *ROS↓, *MMP↑, *Ca+2↓, *Casp3↓, *Ach↑, *PPARγ↑, *PGC-1α↑, *motorD↑, *TNF-α↓, *IL1β↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP↓, *Inflam↓, *antiOx↑, *GutMicro↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1↓, *FASN↓, *ACC↓,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
200- MFrot,  MF,    Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice
- in-vivo, BC, MDA-MB-231 - in-vivo, BC, MCF-7
ALAT↓, TumVol↓, TumCCA↑, TumCG↓, TumMeta↓, Imm↑, P53↑, ALAT↓, AST↓,
3842- Moringa,    Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *hepatoP↑, *lipid-P↓, *ALAT↓, *AST↓, *ALP↓, *creat↓, *RenoP↑, NF-kB↓, ChemoSen↑, *memory?,
3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2↓, eff↑, Bax:Bcl2↑,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,
2344- QC,    Quercetin: A natural solution with the potential to combat liver fibrosis
- Review, Nor, NA
*HK2↓, *PFKP↓, *PKM2↓, *hepatoP↑, *ALAT↓, *AST↓, *Glycolysis↓, *lactateProd↓, *GlucoseCon↓, *CXCL1↓, *Inflam↓,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, NA, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *eff↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2↓, *mTOR↑,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
4488- Se,  Chit,  PEG,    Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats
- in-vivo, Liver, HepG2 - in-vivo, Nor, HL7702
tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,
4601- SeNPs,  AgNPs,    Antioxidant and hepatoprotective role of selenium against silver nanoparticles
- in-vivo, Nor, NA
*TAC↑, *CRP↓, *AST↓, *ALAT↓, *toxicity↓, *GSH↑, *SOD↑, *Catalase↑, *hepatoP↑,
4441- SeNPs,    The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures
- Review, Nor, NA
*ROS↓, *hepatoP↑, *selenoP↑, *ALAT↓, *AST↓, *GSH↑, *GPx↑, *TNF-α↓, *IL6↓, *NF-kB↓, *p65↓, *Dose⇅,
4443- SeNPs,    Bioogenic selenium and its hepatoprotective activity
- in-vivo, LiverDam, NA
*hepatoP↑, *AST↓, *ALAT↓, *LDH↓, *lipid-P?,

Showing Research Papers: 1 to 50 of 74
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 74

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Bil↝, 1,   Catalase↓, 1,   GPx↓, 1,   GSH↓, 3,   HO-1↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 1,   NOX4↓, 1,   NRF2↓, 1,   ROS↓, 2,   ROS↑, 10,   SOD↓, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 1,   FGFR1↓, 2,   MMP↓, 2,   MMP↑, 1,   mtDam↑, 2,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 14,   cMyc↓, 4,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 2,   LDL↓, 1,   PDK1↓, 1,   PKM2↓, 1,   PPARα↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 7,   BAX↓, 1,   BAX↑, 6,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-xL↓, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 6,   Casp7↑, 1,   Casp8↑, 4,   Casp9↑, 3,   cl‑Casp9↑, 1,   cFLIP↓, 1,   CK2↓, 1,   Cyt‑c↑, 7,   FADD↑, 2,   Fas↑, 4,   hTERT/TERT↓, 1,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 2,   Mcl-1↓, 1,   NOXA↑, 1,   p38↑, 2,   PUMA↑, 1,  

Transcription & Epigenetics ⓘ

pRB↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 2,   p‑PERK↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   Beclin-1↑, 2,   BNIP3↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNAdam↑, 3,   P53↑, 6,   PARP↑, 2,   cl‑PARP↑, 3,   PCNA↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   CDK4↓, 6,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↑, 1,   P21↑, 6,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CDK8↓, 1,   p‑cMET↑, 1,   EMT↓, 4,   ERK↓, 6,   p‑ERK↑, 1,   FGF↓, 1,   FGFR2↓, 1,   FOXO3↓, 1,   GSK‐3β↓, 1,   HDAC↓, 3,   mTOR↓, 3,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↑, 1,   P90RSK↓, 1,   PI3K↓, 6,   PTEN↑, 2,   p‑PTEN↓, 1,   RAS↑, 1,   Shh↓, 2,   STAT3↓, 5,   p‑STAT3↓, 2,   TOP1↓, 1,   TRPM7↓, 1,   TumCG↓, 4,   tyrosinase↓, 1,   Wnt↓, 1,  

Migration ⓘ

AXL↓, 1,   Ca+2↑, 1,   CLDN1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 3,   F-actin↓, 1,   p‑FAK↓, 1,   p‑FAK↑, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 7,   MMP9↓, 7,   MMPs↓, 2,   N-cadherin↓, 1,   PDGF↓, 1,   Slug↓, 1,   Smad1↑, 1,   Snail↓, 2,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TumCI↓, 2,   TumCMig↓, 4,   TumCP↓, 4,   TumMeta↓, 5,   Twist↓, 3,   Vim↓, 3,   ZEB2↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   EGFR↓, 2,   Hif1a↓, 3,   VEGF↓, 11,   VEGFR2↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 5,   COX2↑, 1,   CXCc↓, 1,   CXCR4↓, 2,   HMGB1↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 3,   MCP1↓, 1,   NF-kB↓, 8,   PGE2↓, 3,   TLR4↓, 1,   TNF-α↓, 4,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,   ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 3,   ChemoSen↑, 4,   Dose?, 1,   Dose↝, 3,   eff↑, 7,   eff∅, 1,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AFP↓, 2,   ALAT↓, 14,   ALP↓, 6,   AR↓, 1,   AST↓, 11,   Bil↝, 1,   BMPs↑, 1,   creat↓, 2,   EGFR↓, 2,   hTERT/TERT↓, 1,   IL6↓, 4,   Ki-67↓, 1,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 2,   AntiTum↑, 1,   cardioP↑, 3,   chemoP↑, 5,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 6,   neuroP↑, 2,   OS↓, 1,   OS↑, 3,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   TumVol↓, 1,   Weight↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 219

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 18,   Bil↓, 1,   Catalase↑, 19,   Ferroptosis↓, 1,   GPx↓, 2,   GPx↑, 12,   GSH↓, 1,   GSH↑, 22,   GSR↑, 4,   GSSG↓, 1,   GSTA1↑, 2,   GSTs↑, 3,   H2O2↓, 1,   HO-1↑, 6,   Keap1↓, 2,   lipid-P?, 1,   lipid-P↓, 13,   MDA↓, 18,   MPO↓, 3,   NQO1↑, 3,   NRF2↓, 1,   NRF2↑, 12,   ROS↓, 28,   selenoP↑, 1,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 22,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 1,   Thiols↑, 1,   TrxR1↑, 1,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   mtDam↓, 1,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ALAT↓, 37,   AMPK↑, 6,   p‑AMPK↑, 1,   BUN↓, 1,   CRM↑, 2,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   H2S↑, 1,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 8,   LDH↑, 1,   LDL↓, 1,   NADPH↓, 1,   PFKP↓, 1,   PKM2↓, 1,   PPARα↑, 1,   PPARγ↑, 2,   SIRT1↑, 4,   SREBP1↓, 2,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 4,   BAX↓, 1,   Casp1↓, 1,   Casp3↓, 3,   cl‑Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 6,   JNK↓, 1,   MAPK↓, 1,   necrosis↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 2,   ER Stress↓, 2,   NQO2↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,   cl‑PARP1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   mTOR↑, 2,   PI3K↓, 1,   p‑STAT3↓, 1,   TRPM7↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 2,   Ca+2↓, 2,   Cartilage↑, 1,   COL3A1↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TXNIP↓, 1,   ZO-1↑, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 1,   ATF4↓, 1,   eNOS↓, 1,   NO↓, 4,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 9,   COX2↑, 1,   CRP↓, 2,   CXCL1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   IKKα↑, 1,   IL10↓, 2,   IL10↑, 2,   IL18↓, 1,   IL1β↓, 5,   IL2↓, 1,   IL22↓, 1,   IL5↓, 1,   IL6↓, 10,   IL8↓, 2,   Imm↑, 3,   Inflam↓, 17,   Inflam↑, 1,   p‑JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 13,   p65↓, 1,   PGE2↓, 5,   TLR4↓, 2,   TNF-α↓, 12,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   NLRP3↓, 4,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 5,   eff↑, 8,   Half-Life↝, 1,   P450↓, 1,   P450↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 37,   ALP↓, 12,   AST↓, 37,   BG↓, 1,   Bil↓, 1,   BP↓, 2,   creat↓, 3,   CRP↓, 2,   GutMicro↑, 2,   IL6↓, 10,   Ki-67↓, 1,   LDH↓, 8,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 2,   cardioP↑, 10,   chemoP↑, 1,   cognitive↑, 6,   hepatoP↑, 29,   memory?, 1,   memory↑, 4,   motorD↑, 3,   neuroP↑, 12,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 7,   Strength↑, 1,   toxicity↓, 2,   toxicity⇅, 1,   toxicity∅, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 2,   Sepsis↓, 1,  
Total Targets: 188

Scientific Paper Hit Count for: ALAT, ALT, alanine aminotransferase
6 Selenium NanoParticles
6 Silymarin (Milk Thistle) silibinin
6 Thymoquinone
5 Carvacrol
4 Silver-NanoParticles
3 Baicalein
3 Shikonin
2 Resveratrol
2 Curcumin
2 Boron
2 Selenium
2 Chemotherapy
2 Hydrogen Gas
2 Honokiol
2 Moringa oleifera
2 Propolis -bee glue
2 Rosmarinic acid
2 Sulforaphane (mainly Broccoli)
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Ashwagandha(Withaferin A)
1 Berberine
1 Betulinic acid
1 Boswellia (frankincense)
1 Caffeic acid
1 Carnosic acid
1 Thymol-Thymus vulgaris
1 Celastrol
1 Chrysin
1 diet Short Term Fasting
1 Ellagic acid
1 Ferulic acid
1 Shilajit/Fulvic Acid
1 Luteolin
1 Lycopene
1 Metformin
1 Magnetic Field Rotating
1 Magnetic Fields
1 Piperine
1 Quercetin
1 Rutin
1 chitosan
1 polyethylene glycol
1 Date Fruit Extract
1 Cisplatin
1 Ursolic acid
1 Vitamin B5,Pantothenic Acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:554  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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