Furin Cancer Research Results

Furin, Furin: Click to Expand ⟱
Source:
Type:
Furin is a type of protease enzyme that plays a crucial role in the processing and activation of various proteins involved in cell growth, differentiation, and survival.
Furin is overexpressed in many types of cancer, including breast, lung, colon, and prostate cancer. This overexpression can lead to the activation of various oncogenic proteins, such as growth factors, receptors, and adhesion molecules, which can promote tumor growth, invasion, and metastasis.
Furin can activate growth factors such as TGF-β, PDGF, and VEGF, which can promote tumor growth and angiogenesis.
Scientific Papers found: Click to Expand⟱
3436- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights Author links open overlay panel
- in-vitro, BC, MCF-7
ChemoSen↑, LA also enhanced the sensitivity of breast cancer spheroids to doxorubicin (Dox), demonstrating a synergistic effect.
PI3K↓, LA inhibits PI3K/AKT signaling in breast cancer spheroids
Akt↓,
ATP↓, found that LA markedly reduced both ATP levels and glucose uptake
GlucoseCon↓,
ROS↑, LA also induced ROS generation in both MCF-7 and MDA-MB231 spheroids
PKM2↓, LA downregulated the expression of PKM2 and LDHA in the spheroids, indicating an inhibition of glycolysis in BCSCs
Glycolysis↓,
CSCs↓,
IGF-1R↓, LA inhibits IGF-1R via furin downregulation, synergizes with other anticancer drugs like paclitaxel and cisplatin, and enhances radiosensitivity in breast cancer
Furin↓,
RadioS↑,

279- ALA,    Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Furin↓,
IGF-1R↓,
ROS↑, LA (0.5 and 1 mM) exerts its anticancer effects in the context of ovarian cancer by inducing the generation of reactive oxygen species (ROS)
CREB↓, we then demonstrated that this oxidative stress induced by LA is essential to inhibit CREB expression
Furin↓, reduction of furin expression is the consequence of the downregulation of CREB
IGF-1R↓, All of these events contribute to an inhibition of IGF-1R maturation

262- ALA,    Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCP↓,
Akt↓,
ERK↓,
IGF-1R↓,
Furin↓,
Ki-67↓,
AMPK↑,
mTOR↓,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   CREB↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   ERK↓, 1,   IGF-1R↓, 4,   mTOR↓, 1,   PI3K↓, 1,  

Migration ⓘ

Furin↓, 4,   Ki-67↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Furin, Furin
3 Alpha-Lipoic-Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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