TumMeta Cancer Research Results

TumMeta, Cancer Metastasis: Click to Expand ⟱
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Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


Scientific Papers found: Click to Expand⟱
6465- 1,8-Cin,    Eucalyptol targets PI3K/Akt/mTOR pathway to inhibit skin cancer metastasis
- vitro+vivo, Melanoma, NA
TumMeta↓, TumCMig↓, TumCI↓, Vim↓, Snail↓, Slug↓, Twist↓, E-cadherin↓, EMT↓, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓,
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
378- AgNPs,    Antitumor efficacy of silver nanoparticles reduced with β-D-glucose as neoadjuvant therapy to prevent tumor relapse in a mouse model of breast cancer
- ex-vivo, BC, 4T1
TumVol↓, TumMeta↓, Ki-67↓,
4426- AgNPs,    Antiangiogenic properties of silver nanoparticles
- Study, NA, NA
angioG↑, TumCG↓, TumCI↓, TumMeta↓, VEGF↓, PI3K↓, Akt↓,
4549- AgNPs,    Silver nanoparticles: Synthesis, medical applications and biosafety
- Review, Var, NA - Review, Diabetic, NA
ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,
5343- Ajoene,    The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells
- in-vitro, Cerv, HeLa - in-vitro, BC, MDA-MB-231
Vim↑, TumCI↓, TumCMig↓, TumMeta↓, Vim↓, other↝,
5352- AL,    Anticancer potential of allicin: A review
- Review, Var, NA
*cardioP↑, *Bacteria↓, *Inflam↓, AntiTum↑, *DNAdam↓, TumCP↓, angioG↓, TumMeta↓,
284- ALA,    Lipoic acid a multi-level molecular inhibitor of tumorigenesis
- Review, Var, NA
EMT↓, TumMeta↓,
283- ALA,    alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells
- in-vitro, BC, MDA-MB-231
MMP2↓, MMP9↓, TumMeta↓,
1252- aLinA,    α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase
- in-vitro, BC, NA
FASN↓, Apoptosis↑, TumCI↓, TumMeta↓, TumCCA↑,
5358- almon,    Experimental Study of Almonertinib Crossing the Blood-Brain Barrier in EGFR-Mutant NSCLC Brain Metastasis and Spinal Cord Metastasis Models
- vitro+vivo, NSCLC, NA
TumMeta↓, BBB↑, EGFR↓,
1349- And,    Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction
- in-vitro, Lung, H460 - in-vitro, Lung, H1650
TumCG↓, TumMeta↓, Ferroptosis↑, ROS↑, MDA↑, Iron↑, GSH↓, GPx4↓, xCT↓, MMP↓, ATP↓,
6406- ANE,    Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways
- in-vitro, Oral, Ca9-22
TumCP↓, Apoptosis↑, TumAuto↑, ROS↓, GSH↑, cycD1/CCND1↓, P21↑, P53↑, EMT↓, Casp3↑, PARP1↑, TumMeta↓, MMPs↓, TIMP1↑,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
957- ART/DHA,    Artemisinin inhibits the development of esophageal cancer by targeting HIF-1α to reduce glycolysis levels
- in-vitro, ESCC, KYSE150 - in-vitro, ESCC, KYSE170
TumCP↓, TumMeta↓, Glycolysis↓, N-cadherin↓, PKM2↓, Hif1a↓,
985- ART/DHA,    Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway
- in-vitro, Thyroid, TPC-1 - Human, NA, NA
XIST↓, Hif1a↓, Glycolysis↓, TumCCA↑, TumMeta↓,
4993- ART/DHA,    Dihydroartemisinin inhibits galectin-1–induced ferroptosis resistance and peritoneal metastasis of gastric cancer via the Nrf2–HO-1 pathway
- vitro+vivo, GC, NA
Ferroptosis↑, NRF2↓, HO-1↓, PI3K↓, Akt↓, TumMeta↓,
5415- ASA,    The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review
- Review, Var, NA
TumMeta↓, COX1↓, TXA2↓, AntiAg↑, EMT↓, TumCMig↓, TumCI↓, AMPK↑, cMyc↓, PGE2↓, Dose↑, RadioS↑, PD-L1↓, E-cadherin↑, EMT↓, Slug↓, Vim↓, Twist↓, MMP2↓, MMP9↓, other↑,
5408- ASA,    An aspirin a day keeps cancer at bay
- Review, Var, NA
TumMeta↓, TXA2↓, *AntiAg↑, COX1↓,
5409- ASA,    Role of aspirin in cancer prevention
- Review, Var, NA
Imm↑, *Inflam↓, *AntiAg↑, *GutMicro↑, eff↑, TumMeta↓, angioG↓, Risk↓, Risk↓,
5402- ASA,    Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
- Review, Var, NA
COX1↓, TumMeta↓, *Half-Life↓, *COX2↓, *TXA2↓,
1096- ASA,    Aspirin inhibit platelet-induced epithelial-to-mesenchymal transition of circulating tumor cells (Review)
- Review, NA, NA
TumMeta↓, COX1↓, CTC↓,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
4660- Ash,    Withaferin A Alone and in Combination with Cisplatin Suppresses Growth and Metastasis of Ovarian Cancer by Targeting Putative Cancer Stem Cells
- in-vitro, Ovarian, NA
CSCs↓, TumCG↓, TumMeta↓, CD44↓, CD34↓, OCT4↓, NOTCH1↓, HEY1↓,
1146- AsP,    Potential use of nanoformulated ascorbyl palmitate as a promising anticancer agent: First comparative assessment between nano and free forms
- in-vivo, Nor, NA
TumCCA↑, Apoptosis↑, IL6↓, STAT3↓, angioG↓, TumMeta↓, VEGF↓, MMP9↓, SOD↑, Catalase↑, GSH↓, MDA↓, NO↓, *BioAv↑,
5384- AsP,  MEL,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
4812- ASTX,    Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a
- in-vitro, CRC, HCT116
miR-29b↑, miR-200b↑, MMP2↓, Zeb1↓, EMT↓, Apoptosis↑, ERK↓, MAPK↓, PI3K↓, Akt↓, MMPs↓, TumMeta↓,
4811- ASTX,    Astaxanthin reduces MMP expressions, suppresses cancer cell migrations, and triggers apoptotic caspases of in vitro and in vivo models in melanoma
- vitro+vivo, Melanoma, A375 - vitro+vivo, Melanoma, A2058
ROS↓, MMPs↓, TumCMig↓, TumMeta↓, TumCCA↑, antiOx↑, MMP1↓, MMP2↓, MMP9↓,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- NA, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, eff↑, OS↑, Remission↑,
5567- B-Gluc,    Trained immunity: A new player in cancer immunotherapy
- Review, Var, NA
Imm↑, ROS↑, Apoptosis↑, OS↑, TumMeta↓, Dose↝,
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
5540- BBM,    Berbamine Inhibits Cell Proliferation and Migration and Induces Cell Death of Lung Cancer Cells via Regulating c-Maf, PI3K/Akt, and MDM2-P53 Pathways
- vitro+vivo, NSCLC, NA
TumCMig↓, TumCI↓, PI3K↓, Akt↓, MDM2↓, TumCP↓, TumMeta↓,
5543- BBM,    Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo
- in-vivo, Lung, B16-F10 - vitro+vivo, Lung, A549 - in-vitro, BC, MDA-MB-231
BioAv↓, Half-Life↓, eff↑, TumMeta↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, MMP2↓, MMP9↓, VEGF↓, Bcl-2↓, eff↑, EPR↑,
5551- BBM,    Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis
- vitro+vivo, Bladder, NA
tumCV↓, TumCP↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, EMT↓, TumMeta↓, p65↓, p‑p65↓, IKKα↓, NF-kB↑, ROS↑, NRF2↓, HO-1↓, SOD2↓, GPx1↓, Bax:Bcl2↑, TumVol↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
5635- BCA,    Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1
- vitro+vivo, Lung, NA
AntiCan↑, ChemoSen↑, Zeb1↓, TumMeta↓,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2↓, iNOS↓, IL6↓, VEGF↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
2727- BetA,    Betulinic acid in the treatment of breast cancer: Application and mechanism progress
- Review, BC, NA
mt-ROS↑, Sp1/3/4↓, TumMeta↓, GlucoseCon↓, NF-kB↓, ChemoSen↑, chemoP↑, m-Apoptosis↑, TOP1↓,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1↓, PDK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
5715- BF,    Bufalin for an innovative therapeutic approach against cancer
- Review, Var, NA
selectivity↑, TumCP↓, TumCCA↓, TumCD↑, Apoptosis↑, TumAuto↑, TumMeta↓, TumCMig↓, TumCI↓, angioG↓, CSCs↓,
5686- BJ,  BRU,    A review of Brucea javanica: metabolites, pharmacology and clinical application
- Review, Var, NA
AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,

Showing Research Papers: 1 to 50 of 259
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 259

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   Ferroptosis↑, 3,   GPx1↓, 1,   GPx4↓, 3,   GSH↓, 2,   GSH↑, 1,   HO-1↓, 2,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   NRF2↓, 4,   NRF2↑, 1,   NRF2↝, 1,   ROS↓, 3,   ROS↑, 21,   mt-ROS↑, 1,   SOD↑, 1,   SOD2↓, 1,   xCT↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   ATP↓, 2,   BCR-ABL↓, 1,   CDC25↓, 3,   MEK↓, 1,   MMP↓, 7,   Mortalin↓, 1,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   AMPK↑, 3,   cMyc↓, 5,   ECAR↓, 1,   FASN↓, 2,   GlucoseCon↓, 2,   Glycolysis↓, 5,   HMG-CoA↓, 1,   lactateProd↓, 2,   LDHA↓, 1,   LDL↓, 1,   PDK1↓, 1,   p‑PDK1↓, 1,   PKM2↓, 2,   PPARγ↑, 1,   SIRT1↓, 1,   SREBP1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 14,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 19,   m-Apoptosis↑, 1,   BAD↓, 1,   BAX↑, 8,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 3,   Casp1↑, 1,   Casp3↓, 2,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 7,   cl‑Casp9↑, 1,   CK2↓, 2,   Cyt‑c↑, 6,   DR5↑, 3,   FADD↑, 1,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↑, 3,   HEY1↓, 1,   IAP1↓, 2,   IAP2↓, 1,   cl‑IAP2↑, 1,   iNOS↓, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 4,   Mcl-1↓, 2,   MDM2↓, 3,   Myc↓, 1,   p27↑, 2,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 3,   Telomerase↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   other↝, 3,   p‑pRB↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 2,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 2,   GRP78/BiP↑, 3,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   HSPs↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 2,   LC3II↑, 1,   p62↑, 1,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↑, 6,   DNArepair↓, 1,   m-FAM72A↓, 1,   P53↓, 1,   P53↑, 3,   P53↝, 1,   cl‑PARP↑, 4,   PARP1↑, 2,   PCNA↓, 2,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 2,   E2Fs↓, 1,   P21↑, 8,   RB1↑, 1,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD34↓, 1,   CD44↓, 2,   cMYB↓, 1,   CSCs↓, 4,   EMT↓, 12,   EMT↑, 1,   ERK↓, 5,   p‑ERK↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HH↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 8,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 13,   PTEN↑, 1,   RAS↓, 2,   STAT3↓, 6,   p‑STAT3↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TumCG↓, 11,   TumCG↑, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   AntiAg↑, 2,   AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 3,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cdc42↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 4,   FAK↓, 3,   ITGB4↓, 1,   Ki-67↓, 4,   miR-133a-3p↑, 1,   miR-200b↑, 1,   miR-29b↑, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 13,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 16,   MMPs↓, 7,   N-cadherin↓, 3,   PKCδ↓, 1,   Rho↓, 1,   ROCK1↓, 2,   Slug↓, 3,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 1,   TGF-β↓, 4,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 17,   TumCMig↓, 8,   TumCP↓, 17,   TumCP↑, 1,   TumMeta↓, 50,   Twist↓, 3,   TXNIP↑, 1,   uPA↓, 3,   Vim↓, 7,   Vim↑, 1,   Zeb1↓, 4,   ZEB2↓, 2,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 14,   angioG↑, 1,   EGFR↓, 6,   EPR↑, 3,   HIF-1↓, 2,   Hif1a↓, 8,   NO↓, 1,   TXA2↓, 2,   VEGF↓, 13,   VEGFR2↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   COX1↓, 4,   COX2↓, 7,   ICAM-1↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 5,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 2,   M2 MC↓, 1,   MCP1↓, 1,   NF-kB↓, 10,   NF-kB↑, 1,   p65↓, 1,   p‑p65↓, 1,   PD-L1↓, 1,   PGE2↓, 2,   PSA↓, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 2,   ChemoSen↑, 15,   Dose↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 27,   Half-Life↓, 3,   MRP1/ABCC1↓, 1,   RadioS↑, 4,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   CTC↓, 1,   EGFR↓, 6,   HER2/EBBR2↓, 1,   IL6↓, 5,   Ki-67↓, 4,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 1,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 6,   chemoP↑, 3,   chemoPv↑, 1,   OS↑, 2,   Pain↓, 1,   QoL↑, 2,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 3,   toxicity↓, 2,   toxicity↝, 1,   TumVol↓, 3,  
Total Targets: 291

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 3,   ROS↓, 4,   SOD↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   PKCδ↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,   TXA2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 7,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioEnh↑, 1,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   AST↓, 1,   GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   AntiTum↑, 1,   Bone Healing↑, 1,   cardioP↑, 2,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 4,   Obesity↓, 1,   RenoP↑, 1,   toxicity↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,  
Total Targets: 48

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
14 Curcumin
11 Thymoquinone
8 Eugenol
8 Nimbolide
8 Quercetin
7 Resveratrol
6 Magnetic Fields
6 Bicarbonate(Sodium)
6 Pterostilbene
5 Artemisinin
5 Aspirin
5 chitosan
5 Chrysin
5 Honokiol
5 Phenethyl isothiocyanate
4 brusatol
4 Celastrol
4 Magnetic Field Rotating
4 Piperlongumine
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Silver-NanoParticles
3 Baicalein
3 Berbamine
3 Biochanin A
3 Beta-Caryophyllene
3 Propolis -bee glue
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Chlorogenic acid
3 Cinnamon
3 Disulfiram
3 immunotherapy
3 EGCG (Epigallocatechin Gallate)
3 Gambogic Acid
3 Ursolic acid
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Melatonin
2 Astaxanthin
2 Betulinic acid
2 Brucea javanica
2 Bromelain
2 Boswellia (frankincense)
2 Bruteridin(bergamot juice)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Zinc
2 Coenzyme Q10
2 Vitamin K2
2 Cyclopamine
2 D-limonene
2 Copper and Cu NanoParticles
2 Ellagic acid
2 Fisetin
2 Luteolin
2 Radiotherapy/Radiation
2 Rosmarinic acid
2 Selenium
2 Selenium NanoParticles
2 Urolithin
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 3-bromopyruvate
1 Astragalus
1 Ajoene (compound of Garlic)
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 almonertinib
1 Andrographis
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Atorvastatin
1 beta-glucans
1 Berberine
1 Bufalin/Huachansu
1 borneol
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 urea
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Docetaxel
1 Chocolate
1 Metformin
1 Boron
1 Carica papaya leaf extract
1 Crocetin
1 Cucurbitacin
1 Dasatinib/Phyrago
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Electrical Pulses
1 Ferulic acid
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Genistein (soy isoflavone)
1 Geraniol
1 Graviola
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Ivermectin
1 Sorafenib (brand name Nexavar)
1 Lycopene
1 Magnolol
1 nicotinamide adenine dinucleotide
1 Dichloroacetate
1 Oleuropein
1 Phenylbutyrate
1 Piperine
1 Sanguinarine
1 Psoralidin
1 salinomycin
1 Sulfasalazine
1 Shikonin
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:604  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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