HDL Cancer Research Results
HDL, HDL cholesterol: Click to Expand ⟱
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High-density lipoprotein (HDL) cholesterol is often referred to as "good" cholesterol because it helps transport cholesterol away from the arteries and back to the liver, where it can be processed and removed from the body.
Some research suggests that higher levels of HDL cholesterol may be associated with a lower risk of certain types of cancer. This could be due to HDL's role in reducing inflammation and oxidative stress, both of which are linked to cancer development.
Other studies have indicated that very high levels of HDL cholesterol might be associated with an increased risk of certain cancers.
While higher levels of HDL cholesterol are generally associated with cardiovascular health and may have protective effects against certain cancers, the evidence is mixed, and the implications for cancer risk and prognosis vary by cancer type.
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Scientific Papers found: Click to Expand⟱
DHT↑, testosterone
VitD↑,
HDL↓,
*Dose↝, Subjects were randomly divided into two groups receiving 1 and 2 mg/kg/day carvacrol.
*HDL↓, There was significant reductions in high-density lipoprotein cholesterol (HDL), total bilirubin, amylase, iron, red blood cells (RBC) count, and HCT after one-month treatment with 2 mg/kg/day carvacrol
*Bil↓,
*Iron↓,
*toxicity↓, The results of this phase I study regarding carvacrol effects on healthy subjects, showed clinical safety and tolerability for this agent.
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Review, |
Var, |
NA |
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Review, |
AD, |
NA |
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*other↝, Nimbolide is one of the most potent limonoids derived from the flowers and leaves of neem (Azadirachta indica), which is widely used to treat a variety of human diseases.
*Inflam↓, Nimbolide has anti-inflammatory, anti-microbial, and anti-cancer properties, which make it an intriguing compound for research.
AntiCan↑,
*Bacteria↓, pharmacological properties including antimalaria, antibacterial, antiviral, antioxidative, anti-inflammatory, antiinvasive, neuroprotective, hepatoprotective, and pro-apoptotic properties
*AntiViral↑,
*neuroP↑,
*hepatoP↑,
*ROS?, Inhibit oxidative stress, Activate Nrf2/HO-1 signaling
*NRF2↑,
*HO-1↑,
*TLR4↓, Inhibit oxidative stress Anti-inflammatory and antioxidant TLR4/NF-κB signaling pathway
*NF-kB↓,
*AChE↓, down regulation of AChE and Aβ GSK-3β interaction
*Aβ↓,
*GSK‐3β↓,
*LDL↓, Nimbolide reduced intracellular cholesterol, free fatty acids, and triglycerides and enhanced hepatocyte function by inhibiting oxidative DNA damage and lipid peroxidation through its antioxidant effects
*DNAdam↓,
*lipid-P↓,
*antiOx↑, Nimbolide showed immense antioxidant properties.
*SOD1↑, nimbolide treatment increased superoxide dismutase (SOD-1), Nrf-2, GSH, and HO-1 protein expression
*GSH↑,
*IL6↓, Nimbolide treatment resulted in a reduction of the inflammatory cytokines IL-6, IL-1β, and TNF-α, as well as inflammatory cellular signaling molecules IkB-α, STAT3, and NF-kB.
*IL1β↓,
*STAT3↓,
*GPx↑, Glutathione peroxidase, catalase (CAT), concentration were all found to be up, while malondialdehyde and nitric oxide levels were shown to be significantly reduced by nimbolide.
*Catalase↑,
*MDA↓,
*AntiDiabetic↑, Anti-diabetic effect of nimbolide in diabetes
*HDL↓, suppression of the levels of pro-inflammatory mediators, (cholesterol, TG, LDL, and HDL, MCP-1, VEGF, and MMP-9)
*MCP1↓,
*VEGF↓,
*MMP9↓,
*GutMicro↑, nimbolide showed to reduce inflammation, oxidative stress, and to reverse gut microbiota, which protects them from gestational diabetes.
TumCP↓, Nimbolide reported to decrease cell proliferation, EMT, cell cycle progression, and migration, in breast cancer cells via downregulating the NF-κB pathway
TumCCA↑,
TumCMig↓,
NF-kB↓,
ROS↑, nimbolide stimulates the overproduction of ROS, consequently modulating both autophagy and apoptosis in pancreatic cancer cells.
PI3K↓, nimbolide-induced ROS generation hindered cell proliferation by suppressing PI3K/AKT/mTOR and ERK signaling pathways.
Akt↓,
mTOR↓,
ERK↓,
EMT↓, nimbolide-mediated ROS generation reduced EMT, migration, colony forming abilities and invasion, thereby inhibiting metastasis.
TumMeta↓,
ChemoSen↑, use of nimbolide in combination with 5-FU showed a higher inhibitory rate in breast cancer than 5-FU alone
eff↑, nimbolide synergized the effect of TRAIL to induce apoptosis in tumor cell lines, but not normal breast cells
selectivity↑,
CDK4↓, slows tumor growth by inhibiting CDK4/6 activity
CDK6↓,
Wnt↓, nimbolide suppressed the Wnt/β-catenin signaling pathway mediated by NF-κB in HCC and pancreatic cancer cells
β-catenin/ZEB1↓,
STAT3↓, nimbolide can significantly suppress the activation of oncogenic transcription factor STAT3.
MMP2↓, inhibits tumor cell growth and migration by downregulating VEGF-A and MMP-2/9 expression,
Sp1/3/4↓, nimbolide inhibited MMP-9 activity by inhibiting the binding activity of Sp-1, AP-1 and NFk-B motifs, all of which are important transcription factors.
AP-1↓,
P21↑, Nimbolide exhibited dose-dependent inhibitory effects on HeLa cell viability by causing cell cycle arrest at G0/G1 phase with p53-dependent accumulation of p21.
*AntiArt↑, The findings of the study suggest that nimbolide has the ability to reduce the severity of rheumatoid arthritis by suppressing the expression levels of toll-like receptors, IL-23, IL-17, IFN-γ and HSP70.
*IL23↓,
*IL17↓,
*IFN-γ↓,
*HSP70/HSPA5↓,
Showing Research Papers: 1 to 3 of 3
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
HDL↓, 1, ROS↑, 1,
Cell Death(tgid=5) ⓘ
Akt↓, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
Sp1/3/4↓, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK4↓, 1, P21↑, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
EMT↓, 1, ERK↓, 1, mTOR↓, 1, PI3K↓, 1, STAT3↓, 1, Wnt↓, 1,
Migration(tgid=13) ⓘ
AP-1↓, 1, MMP2↓, 1, TumCMig↓, 1, TumCP↓, 1, TumMeta↓, 1, β-catenin/ZEB1↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
NF-kB↓, 1, VitD↑, 1,
Hormonal & Nuclear Receptors(tgid=20) ⓘ
CDK6↓, 1, DHT↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
ChemoSen↑, 1, eff↑, 1, selectivity↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
VitD↑, 1,
Functional Outcomes(tgid=23) ⓘ
AntiCan↑, 1,
Total Targets: 28
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
AntiArt↑, 1,
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 1, Bil↓, 1, Catalase↑, 1, GPx↑, 1, GSH↑, 1, HDL↓, 2, HO-1↑, 1, Iron↓, 1, lipid-P↓, 1, MDA↓, 1, NRF2↑, 1, ROS?, 1, SOD1↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
LDL↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
other↝, 1,
Protein Folding & ER Stress(tgid=8) ⓘ
HSP70/HSPA5↓, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↓, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
GSK‐3β↓, 1, STAT3↓, 1,
Migration(tgid=13) ⓘ
MMP9↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
VEGF↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
IFN-γ↓, 1, IL17↓, 1, IL1β↓, 1, IL23↓, 1, IL6↓, 1, Inflam↓, 1, MCP1↓, 1, NF-kB↓, 1, TLR4↓, 1,
Synaptic & Neurotransmission(tgid=18) ⓘ
AChE↓, 1,
Protein Aggregation(tgid=19) ⓘ
Aβ↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
Dose↝, 1,
Clinical Biomarkers(tgid=22) ⓘ
Bil↓, 1, GutMicro↑, 1, IL6↓, 1,
Functional Outcomes(tgid=23) ⓘ
AntiDiabetic↑, 1, hepatoP↑, 1, neuroP↑, 1, toxicity↓, 1,
Infection & Microbiome(tgid=24) ⓘ
AntiViral↑, 1, Bacteria↓, 1,
Total Targets: 43
Scientific Paper Hit Count for: HDL, HDL cholesterol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:63 State#:% Dir#:1
wNotes=on sortOrder:rid,rpid
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