Database Query Results : , , SIRT1

SIRT1, Sirtuin 1 protein: Click to Expand ⟱
Source:
Type:
SIRT1 (Sirtuin 1) is a protein that plays a crucial role in various cellular processes, including metabolism, stress resistance, and longevity. In the context of cancer, SIRT1 has been found to have both tumor-suppressing and tumor-promoting functions, depending on the type of cancer and the cellular context.
Expression Promotes: Breast, Prostate, Colorectal Cancer.
Expression Suppresses: Leukemia, Liver Cancers.
-aging process is associated with the inactivation of the silent information regulator T1 (SIRT1) protein.
Scientific Papers found: Click to Expand⟱
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
1517- CAP,    Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
- in-vitro, Bladder, TSGH8301 - in-vitro, CRC, T24
ENOX2↓, TumCCA↑, ERK↓, p‑FAK↓, p‑pax↓, TumCMig↓, EMT↓, SIRT1↓, Dose∅, ROS↑, MMP↓, Bcl-2↓, Bak↑, cl‑PARP↑, Casp3↑, SIRT1↓, ac‑P53↑, BIM↑, p‑RB1↓, cycD1↓, Dose∅, β-catenin/ZEB1↓, N-cadherin↓, E-cadherin↑,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoP↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1↓, cycE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1961- GamB,    Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS
- in-vitro, Melanoma, RPMI-8226
TumCG↓, Apoptosis↑, ROS↑, Casp3↑, cl‑PARP↑, SIRT1↓, eff↓,
2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, OS↑, Dose↝, Dose↝, CEA↓, CA125↓, CYFRA21-1↓, SIRT1↓, COX2↓, IL1β↓, IL6↓, TNF-α↓, HMGB1↓, NF-kB↓, EP2↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2589- LT,  Chemo,    Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway
- in-vitro, BC, MDA-MB-231
NRF2↓, HO-1↓, ChemoSen↑, CSCs↓, SIRT1↓,
2077- PB,    Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells
- in-vitro, Liver, HUH7
miR-22↑, SIRT1↓, ROS↑, Cyt‑c↑, Casp3↑, eff↓, TumCG↓, TumCP↓, HDAC↓, SIRT1↓, CD44↓, proMMP2↓, MMP↓, SOD↓,
2339- QC,    Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *Sepsis↓, *PKM2↓, *SIRT1↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, *NA↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Results for Effect on Cancer/Diseased Cells:
AIF↑,2,   Akt↓,4,   Akt↑,1,   p‑Akt↓,2,   ALDH↓,1,   AMPK↑,2,   angioG↓,3,   AntiCan↑,3,   antiOx↓,1,   Apoptosis↑,4,   AR↓,2,   ASC↓,1,   ATP↓,1,   AXL↓,1,   Bak↑,1,   BAX↑,2,   Bax:Bcl2↑,1,   Bcl-2↓,4,   Bcl-xL↓,2,   BIM↑,1,   BioAv↓,3,   BioAv↑,1,   BioAv↝,1,   CA↓,1,   Ca+2↑,1,   Ca+2↝,1,   CA125↓,1,   cachexia↓,1,   cardioP↑,2,   Casp↑,2,   Casp1↓,1,   Casp3↑,7,   Casp7↑,1,   Casp8↑,1,   Casp9↑,2,   Catalase↓,2,   CD34↓,1,   CD44↓,3,   Cdc42↓,1,   CDH1↑,1,   CDK2↓,1,   CDK2↑,1,   CDK4↓,1,   CDK6↓,3,   CDK8↓,1,   CEA↓,2,   cFos↑,1,   chemoP↑,3,   ChemoSen↑,4,   ChemoSen⇅,1,   ChemoSideEff↓,1,   CHOP↑,2,   CIP2A↓,1,   CLDN1↓,1,   cMyc↓,3,   COX1↓,1,   COX2↓,5,   CSCs↓,2,   cSrc↓,1,   CXCR4↓,2,   cycD1↓,4,   cycE↓,1,   CYFRA21-1↓,1,   CYP1A1↓,1,   Cyt‑c↑,5,   Diablo↑,1,   DNAdam↓,1,   DNAdam↑,1,   DNMT1↓,2,   DNMT3A↓,1,   DNMTs↓,1,   Dose↝,4,   Dose∅,3,   DR4↑,1,   DR5↑,2,   E-cadherin↓,1,   E-cadherin↑,5,   ECAR↝,1,   eff↓,2,   eff↑,6,   eff↝,1,   EGFR↓,2,   EGFR↑,1,   p‑eIF2α↑,1,   EMT↓,7,   Endoglin↑,1,   ENOX2↓,1,   EP2↓,1,   ER Stress↑,1,   ERK↓,2,   p‑ERK↓,1,   EZH2↓,2,   FAK↓,2,   p‑FAK↓,2,   Fas↑,1,   FasL↑,1,   FOXO1↓,1,   FOXO3↑,1,   GlucoseCon↓,1,   GLUT1↓,1,   Glycolysis↓,1,   GPx↓,2,   GSH↓,2,   GSR↓,1,   GSTs↓,1,   GSTs↑,1,   H3↓,1,   H4↓,1,   Half-Life↓,1,   Half-Life↝,1,   HATs↑,2,   HDAC↓,5,   HDAC1↓,2,   HDAC2↓,1,   HDAC3↓,1,   HDAC8↓,1,   hepatoP↑,2,   HGF/c-Met↓,1,   Hif1a↓,4,   HK2↓,1,   HMGB1↓,1,   HMTs↑,1,   HO-1↓,4,   HO-2↓,1,   hTERT↓,1,   ICAM-1↓,1,   IGFBP3↑,1,   IKKα↓,1,   IL1↓,1,   IL1β↓,1,   IL2↑,1,   IL6↓,3,   Inflam↓,1,   iNOS↓,1,   ITGB1↓,1,   JAK↓,1,   JAK2↓,1,   JNK↑,1,   p‑JNK↑,1,   Ki-67↓,2,   lactateProd↓,1,   LC3II↑,2,   LDH↓,1,   MAD↓,1,   MALAT1↓,1,   MAPK↓,2,   Mcl-1↓,1,   MDM2↓,1,   p‑MDM2↓,1,   MDR1↓,1,   MET↓,1,   p‑MET↓,1,   miR-203↑,1,   miR-22↑,1,   MMP↓,6,   MMP↑,1,   MMP2↓,4,   proMMP2↓,1,   MMP7↓,1,   MMP9↓,4,   mTOR↓,2,   Myc↓,1,   N-cadherin↓,3,   NADPH↑,1,   Nanog↓,1,   Nestin↓,1,   NF-kB↓,8,   NHE1↓,2,   NLRP3↓,1,   NOTCH↓,4,   NOTCH1↓,1,   NOXA↑,1,   NQO1↓,1,   NRF2↓,2,   NSE↓,1,   OCR↓,1,   OS↑,1,   other↓,1,   P21↑,3,   p27↑,1,   p‑p38↑,1,   P450↓,1,   P53↑,2,   ac‑P53↑,1,   p‑p65↓,1,   PARP↑,1,   cl‑PARP↑,5,   p‑pax↓,1,   PCNA↓,2,   PD-1↓,2,   PD-L1↓,2,   PDGF↓,1,   PDH↝,1,   PDK1?,2,   PGE2↓,1,   PI3K↓,3,   p‑PI3K↓,1,   PKCδ↓,2,   PPARγ↓,1,   PSA↓,1,   PTEN↓,2,   PTEN↑,3,   PUMA↑,1,   Rac1↓,1,   RadioS↑,5,   RARβ↑,1,   p‑RB1↓,2,   Rho↓,1,   ROS↓,2,   ROS↑,10,   selectivity↑,3,   Shh↓,1,   SIRT1↓,16,   SIRT2↓,1,   SIRT6↑,1,   Slug↓,1,   SMAD3↓,1,   Snail↓,3,   SOD↓,3,   SOD2↓,1,   p‑Src↓,1,   SREBP1↓,1,   STAT3↓,4,   p‑STAT3↓,2,   p‑STAT6↓,1,   survivin↓,3,   TCF↓,1,   Telomerase↓,2,   TET2↑,1,   TGF-β↓,2,   TGF-β↑,1,   TNF-α↓,1,   TOP2↓,1,   toxicity↝,1,   toxicity∅,1,   TP53↑,1,   TumAuto↑,1,   TumCCA↑,4,   TumCG↓,5,   TumCI↓,1,   TumCMig↓,2,   TumCP↓,3,   tumCV↓,1,   TumMeta↓,1,   TumVol↓,1,   Twist↓,2,   Tyro3↓,1,   uPA↓,1,   VEGF↓,6,   VEGFR2↓,2,   Vim↓,4,   Vim↑,1,   VitC↓,1,   VitE↓,1,   Warburg↓,1,   Wnt↓,2,   Wnt/(β-catenin)↓,1,   XIAP↓,3,   Zeb1↓,2,   ZO-1↑,1,   β-catenin/ZEB1↓,4,  
Total Targets: 261

Results for Effect on Normal Cells:
angioG↑,1,   antiOx↑,2,   BioAv↓,3,   cardioP↑,1,   Casp3↓,1,   Catalase↑,2,   CRP↓,1,   eff↑,2,   GPx↑,2,   GSH↑,3,   GSTs↑,1,   Half-Life↝,1,   hepatoP↑,1,   HO-1↑,1,   IL10↑,1,   IL1β↓,2,   IL6↓,1,   IL8↓,1,   Inflam↓,4,   iNOS↓,1,   lipid-P↓,1,   MDA↓,2,   memory↑,1,   NA↓,1,   NAD↑,1,   neuroP↑,2,   NHE3↑,1,   NLRP3↓,1,   NO↓,2,   NRF2↑,1,   PI3K↑,1,   PKM2↓,1,   RenoP↑,1,   ROS↓,1,   Sepsis↓,1,   SIRT1↓,2,   SIRT1↑,3,   SOD↑,3,   TAC↑,1,   TIMP1↓,1,   TNF-α↓,2,  
Total Targets: 41

Scientific Paper Hit Count for: SIRT1, Sirtuin 1 protein
2 Capsaicin
2 Ellagic acid
2 Luteolin
1 alpha Linolenic acid
1 Gambogic Acid
1 Hydrogen Gas
1 Chemotherapy
1 Phenylbutyrate
1 Quercetin
1 Resveratrol
1 Rosmarinic acid
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Thymoquinone
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:634  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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