COMT Cancer Research Results

COMT, catechol-O-methyl transferase: Click to Expand ⟱
Source:
Type:
Catechol-O-methyltransferase (COMT) is an enzyme located in the frontal cortex of the brain that metabolizes epinephrine, norepinephrine, and dopamine.
Genetic polymorphisms in the COMT gene can influence enzyme activity and may be associated with the risk of certain cancers.
COMT is involved in the metabolism of estrogens, particularly catechol estrogens, which can have both proliferative and genotoxic effects on breast tissue. Dysregulation of estrogen metabolism has been implicated in the development of hormone-related cancers.
Scientific Papers found: Click to Expand⟱
25- EGCG,  QC,    Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
COMT↓, fact that EGCG primarily inhibited COMT activity, whereas quercetin reduced the amount of COMT protein.
TumCP↑, Quercetin and EGCG in combination synergistically inhibited cell proliferation, caused cell cycle arrest, and induced apoptosis in PC-3 cells.
TumCCA↑,
Apoptosis↑,

81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓,
MRP1↓,
Ki-67↓,
Bax:Bcl2↑,
AR↓, significant increase in the inhibition of proliferation, androgen receptor (AR) and phosphatidylinositol 3-kinases (PI3K)/Akt signaling, and stimulation of apoptosis.
Akt↓,
p‑ERK↓, ERK1/2
COMT↓, Increased inhibition of COMT protein and mRNA expression and MRP1 protein expression
eff↑, Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
chemoPv↑, novel regimen by combining GT and Q to improve chemoprevention in a non-toxic manner and warrant future studies in humans.
BioAv↑, Increased bioavailability and decreased methylation of GTPs

980- QC,    Dietary Quercetin Exacerbates the Development of Estrogen-Induced Breast Tumors in Female ACI Rats
- in-vivo, BC, NA
COMT↓, bad
ROS∅, quercetin (2.5 g/kg food) does not confer protection against breast cancer, does not inhibit E2-induced oxidant stress and may exacerbate breast carcinogenesis in E2-treated ACI rats.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS∅, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bax:Bcl2↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,  

Migration ⓘ

Ki-67↓, 1,   TumCP↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   COMT↓, 4,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   eff↑, 1,   MRP1↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: COMT, catechol-O-methyl transferase
3 Quercetin
2 EGCG (Epigallocatechin Gallate)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:64  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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