FTH1 Cancer Research Results

FTH1, ferritin heavy chain: Click to Expand ⟱
Source:
Type:
Ferritin is a protein that stores iron in the body and is made up of two subunits, ferritin light chain (FTL) and ferritin heavy chain (FTH1).
Ferritin heavy chain 1 (FTH1) is one of the two subunits that make up the protein ferritin, which is responsible for storing iron in the body. FTH1 is encoded by the FTH1 gene, which is located on chromosome 11 in humans.

FTH1 expression is often upregulated in various cancers and is generally associated with a poorer prognosis.
Scientific Papers found: Click to Expand⟱
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
2717- BetA,    Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma
- in-vitro, Melanoma, U266 - in-vivo, Melanoma, NA - in-vitro, Melanoma, RPMI-8226
Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, NF-kB↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP1↑, MDA↑, SOD↓, SOD2↓, GCLM↓, GSTA1↓, FTH1↓, GSTs↓, TumVol↓,
2756- BetA,    Betulinic acid inhibits growth of hepatoma cells through activating the NCOA4-mediated ferritinophagy pathway
- in-vitro, HCC, HUH7 - in-vitro, HCC, H1299
TumCP↓, ROS↑, antiOx↓, TumCG↓, TumCMig↓, NRF2↓, GPx4↓, HO-1↓, NCOA4↑, FTH1↓, Ferritin↑, Ferroptosis↑, GSH↓, MDA↓,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
673- EGCG,    Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking
- in-vitro, CRC, HT-29
IronCh↑, TfR1/CD71↑, FTH1↓,
2958- PL,    Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity
- in-vitro, Oral, HSC3
TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT↓, GPx4↓, FTH1↓,
5333- TFdiG,    Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
- vitro+vivo, OS, MG63
tumCV↓, TumCP↓, TumCCA↑, Iron↑, ROS↑, GSH↓, Fenton↑, Ferroptosis↑, Apoptosis↑, MAPK↑, ERK↑, JNK↑, p38↑, TumCG↓, Dose↝, FTH1↓, GPx4↓,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   Fenton↑, 1,   Ferroptosis↑, 6,   GCLM↓, 1,   GPx↓, 1,   GPx4↓, 5,   GSH↓, 5,   GSTA1↓, 1,   GSTs↓, 1,   H2O2↑, 1,   HO-1↓, 1,   Iron↑, 5,   lipid-P↑, 2,   MDA↓, 2,   MDA↑, 4,   NADPH/NADP+↓, 1,   NRF2↓, 2,   ROS↑, 8,   SOD↓, 2,   SOD2↓, 1,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↑, 1,   FTH1↓, 8,   IronCh↑, 1,   NCOA4↑, 3,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,   ATG7↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PFKP↓, 1,   Pyruv↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 4,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 2,   Ferroptosis↑, 6,   JNK↑, 1,   MAPK↑, 1,   p38↑, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↑, 1,   cl‑PARP1↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   TumCG↓, 3,  

Migration ⓘ

Ca+2↓, 1,   TumCMig↓, 2,   TumCP↓, 5,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,   eff↓, 4,  

Clinical Biomarkers ⓘ

Ferritin↑, 1,  

Functional Outcomes ⓘ

TumVol↓, 2,   TumW↓, 1,  
Total Targets: 75

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: FTH1, ferritin heavy chain
2 Betulinic acid
1 Allicin (mainly Garlic)
1 Citric Acid
1 EGCG (Epigallocatechin Gallate)
1 Piperlongumine
1 Sulfasalazine
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:646  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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