ERCC1 Cancer Research Results

ERCC1, Excision Repair Cross Complementation group 1: Click to Expand ⟱
Source:
Type: protein
ERCC1 (Excision Repair Cross Complementation group 1) is a protein that plays a crucial role in the repair of DNA damage caused by environmental factors, such as ultraviolet light and chemicals. It is involved in the nucleotide excision repair (NER) pathway, which is responsible for removing damaged DNA segments and repairing them.

In the context of cancer, ERCC1 has been found to be overexpressed in various types of tumors, including lung, colon, and ovarian cancers.
Scientific Papers found: Click to Expand⟱
441- CUR,    Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p
- in-vitro, CRC, HCT116
ERCC1↓,
Bcl-2↓,
GSTP1/GSTπ↓,
MRP↓,
P-gp/ABCB1↓,
miR-409-3p↑,
survivin↓,

7378- RS,    Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling
*antiOx↑, Reserpine is a natural indole alkaloid isolated from Rauwolfia serpentina and has potent antioxidant, antimicrobial, and anti-mutagenic properties.
*AntiBio↑,
TGF-β↓, reserpine inhibits TGF-β dependent Smad2/3/4 phosphorylation, thereby blockage Smad3/Snail activation and Smad2/4 nuclear translocation.
p‑SMAD3↓,
p‑SMAD2↓,
p‑SMAD4↓,
SMAD3↓,
Snail↓,
ERCC1↓, downregulating ERCC1, XPF, Ku70, DNA-PKcs, PCNA, cyclin D1, HIF-1α, IL-6, Mcl-1
ERCC4/XPF↓,
Ku70/XRCC6↓,
PCNA↓,
cycD1/CCND1↓,
Hif1a↓,
IL6↓,
Mcl-1↓,
BAX↑, stimulates Bax, cytochrome C, Apaf-1, caspase-9, caspase-3 and PARP protein expressions.
Cyt‑c↑,
APAF1↑,
Casp9↑,
Casp3↑,
PARP↑,
DNArepair↓, therapeutic potential of reserpine in inhibiting DNA repair, cell proliferation, and invasion
TumCP↓,
TumCI↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ERCC4/XPF↓, 1,   Ku70/XRCC6↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSTP1/GSTπ↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ERCC1↓, 2,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Mcl-1↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-409-3p↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↓, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Migration(tgid=13) ⓘ

p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MRP↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: ERCC1, Excision Repair Cross Complementation group 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:696  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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