MRP Cancer Research Results

MRP, Multidrug Resistance-Associated Protein: Click to Expand ⟱
Source:
Type:
MRP is a family of ATP-binding cassette (ABC) transporters that are involved in the efflux of various compounds, including chemotherapeutic agents, from cells. There are several members of the MRP family, including MRP1 (ABCC1), MRP2 (ABCC2), MRP3 (ABCC3), and others.
MRP proteins are overexpressed in various types of cancer, including breast, lung, colon, and leukemia. This overexpression can lead to the efflux of chemotherapeutic agents from cancer cells, making them resistant to treatment.
Scientific Papers found: Click to Expand⟱
6123- CHr,    Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms
- Review, Nor, NA
*eff↓, . A potential reason for chrysin’s low efficacy in humans is poor oral bioavailability
*BioAv↓, Low aqueous solubility, rapid metabolism mediated by UGTs and SULT, efficient excretion through efflux transporters including BCRP and MRP2 are the major reasons causing poor systemic bioavailability for chrysin.
*eff↑, chrysin can be ideal for treating diseases in the terminal ileum and colon (e.g., carcinoma, local infection) since it is localized in the lower GI tract with limited delivery to other organs.
*BioAv↓, It was reported that chrysin’s absolute oral bioavailability is ~1%
OATPs↓, vitro studies demonstrated that chrysin and chrysin conjugates also inhibit CYPs [83], [84]and transporters including OATPs, MRP2
MRP↓,

441- CUR,    Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p
- in-vitro, CRC, HCT116
ERCC1↓,
Bcl-2↓,
GSTP1/GSTπ↓,
MRP↓,
P-gp/ABCB1↓,
miR-409-3p↑,
survivin↓,

6975- Form,    Formononetin inhibits colorectal cancer via the miR-490-3p/ABCC2 axis and synergizes with 5-fluorouracil: mechanistic insights and therapeutic implications
- vitro+vivo, CRC, NA
TumCP↓, results demonstrated that FMNT markedly suppresses CRC proliferation in vitro and tumorigenesis in vivo
MRP↓, FMNT markedly downregulated the MRP2 expression.
miR-490↑, Mechanistically, FMNT upregulated tumor-suppressive miR-490-3p, which directly targets the ABCC2 3'UTR
eff⇅, Notably, overexpression of miR-490-3p augmented FMNT's antitumor effects, whereas inhibition of miR-490-3p diminished its efficacy.
ChemoSen↑, robust synergy between FMNT and 5-FU, with combination therapy achieving superior tumor growth inhibition compared to monotherapies
ABCC2↓, FMNT's antitumor activity and highlight its potential for chemosensitization through ABCC2 inhibition

2133- TQ,  CUR,  Cisplatin,    Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling
- in-vitro, Nor, HEK293 - in-vivo, NA, NA
*creat↓, BUN, creatinine, CK and pro-inflammatory cytokines like TNF-α, IL-6 and MRP-1 to be elevated in the cisplatin-treated group while reducing glomerular filtration rate. Tq + Cur treatment significantly improved these conditions.
*TNF-α↓,
*IL6↓,
*MRP↓,
*GFR↑,
*mt-ATPase↑, antioxidant enzyme levels and mitochondrial ATPases were restored upon treatment,
*p‑Akt↑, Tq + Cur treatment increased the expressions of phosphorylated Akt, Nrf2 and HO-1 proteins while decreasing the levels of cleaved caspase 3 and NFκB in kidney homogenates.
*NRF2↑,
*HO-1↑,
*Casp3↓,
*NF-kB↓,
*RenoP↑, In summary, Tq + Cur had protective effects on cisplatin-induced nephrotoxicity and renal injury


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCC2↓, 1,   miR-490↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSTP1/GSTπ↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ERCC1↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-409-3p↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MRP↓, 3,   OATPs↓, 1,   P-gp/ABCB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff⇅, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   NRF2↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   Casp3↓, 1,  

Migration(tgid=13) ⓘ

mt-ATPase↑, 1,  

Barriers & Transport(tgid=15) ⓘ

MRP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   eff↓, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

creat↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

GFR↑, 1,   RenoP↑, 1,  
Total Targets: 16

Scientific Paper Hit Count for: MRP, Multidrug Resistance-Associated Protein
2 Curcumin
1 Chrysin
1 Formononetin
1 Thymoquinone
1 Cisplatin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:697  State#:%  Dir#:1
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