CTNNB1 Cancer Research Results

CTNNB1, catenin (cadherin-associated protein), beta 1, 88kDa: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
CTNNB1, which encodes the protein beta-catenin, plays a significant role in the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and adhesion. Mutations in the CTNNB1 gene can lead to the stabilization and accumulation of beta-catenin in the cytoplasm and nucleus, resulting in the activation of Wnt target genes that promote oncogenesis.
CTNNB1 mutations are commonly associated with several types of cancer.
CTNNB1 (which encodes beta-catenin) is considered an oncogene when it is mutated or dysregulated. Overall, CTNNB1 expression and its mutations are often associated with poor prognosis across various cancer types.
Scientific Papers found: Click to Expand⟱
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
tumCV↓, MDA-MB-231 showed more sensitivity than the MCF-7 cell line to the anticancer activity of mummy,
selectivity↑, while mummy did not exhibit significant cell cytotoxicity against human normal cells (MCF-10A).
TGF-β↓, gene expression profile demonstrated a significant decrease in TGF-β1, TGF-βR1, TWIST1, NOTCH1, CTNNB1, SRC along with an increase in E-cadherin mRNA levels in mummy treated cells compared to the untreated control group
Twist↓,
NOTCH1↓,
CTNNB1↓,
Src↓,
E-cadherin↑,
EMT↓, Mummy triggers inhibition of EMT and metastasis in breast cancer cells mainly through the downregulation of TGFβ1 activity
TumMeta↓,
BioAv↑, water-soluble non-toxic and inexpensive compound, can be consumed as a part of the daily diet

5017- UA,    Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells
- in-vitro, Cerv, INT-407 - in-vitro, CRC, HCT116
AntiCan↑, Ursolic acid is a natural compound possessing several therapeutic properties including anticancer potential.
TumCG↓, intestinal cancer cell lines INT-407 and HCT-116. The cells growth and number were decreased in a dose- and time-dependent manner in both the cell lines.
ROS↑, It also increases reactive oxygen species levels in the cells in order to induce apoptosis.
Apoptosis↑,
TumCMig↓, significant inhibitor of cancer cells migration and gene expression of migration markers FN1, CDH2, CTNNB1 and TWIST was also downregulated.
CTNNB1↓,
Twist↓,
Bcl-2↓, Ursolic acid treatment downregulated the gene expression of survival factors BCL-2, SURVIVIN, NFKB and SP1
survivin↓,
NF-kB↓,
Sp1/3/4↓,
BAX↑, while upregulated the growth-restricting genes BAX, P21 and P53.
P21↑,
P53↑,
eff↓, The UA-induced oxidative stress was reversed by 5 mM NAC treatment.
TumCMig↓, Ursolic acid restricts the migration ability of cancer cells


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CTNNB1↓, 2,   EMT↓, 1,   NOTCH1↓, 1,   Src↓, 1,   TumCG↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   TGF-β↓, 1,   TumCMig↓, 2,   TumMeta↓, 1,   Twist↓, 2,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   eff↓, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CTNNB1, catenin (cadherin-associated protein), beta 1, 88kDa
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:70  State#:%  Dir#:1
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