miR-130a Cancer Research Results

miR-130a, miR-130a microRNA: Click to Expand ⟱
Source:
Type: microRNA
MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in regulating gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or inhibition of translation.
miR-130a is overexpressed in several types of cancer: breast, lung, CRC, ovarian.
key targets of miR-130a: Tp53, PTEN, SMAD4, RUNX3.

miR-130a is generally considered protumorigenic in many contexts. Its ability to target and downregulate tumor suppressor genes can facilitate tumor growth, invasion, and metastasis.
Scientific Papers found: Click to Expand⟱
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓,
TumCI↓,
TumCMig↓,
Apoptosis↑,
ROS↑,
miR-21↓,
miR-130a↓,
Casp8∅, Caspase-8, Caspase-10, Cyclin D1, Cyclin D2, CDK6, CDK4, FADD, TRADD, FAS, DR4 and DR5 gene mRNA expression changes were found insignificant in boric acid treated group compared with control
Casp10∅,
cycD1/CCND1∅,
CDK6∅,
CDK4∅,
FADD∅,
DR4∅,
DR5∅,

449- CUR,    Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a
- vitro+vivo, CRC, SW480
TumCP↓,
β-catenin/ZEB1↓,
TCF↓, TCF4
miR-21↓,
NKD2↑,
miR-130a↓, main target affecting others

4709- CUR,    Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
- Review, Var, NA
miR-21↓, Curcumin can effectively repress the miR-21/PTEN/Akt molecular pathway to inhibit cell proliferation and induce apoptosis in gastric cancer cells
TumCP↓, Curcumin can inhibit the proliferation, migration, invasion and promote apoptosis of retinoblastoma cells, which function through up-regulating the miR-99a expression and then inhibiting JAK/STAT signaling pathway
TumCMig↓,
TumCI↓,
Apoptosis↑,
miR-99↑,
JAK↓,
STAT↓,
cycD1/CCND1↓, curcumin can suppress the cell proliferation by down-regulations of cyclinD1 and up-regulations of p21 expression.
P21↑,
ChemoSen↑, curcumin combined with chemotherapy drugs may play a better therapeutic effect via JAK/STAT signaling pathway
miR-192-5p↑, curcumin enhanced the expression level of miR−192−5p and decreased the expression of c−Myc.
cMyc↓,
Wnt↓, curcumin suppresses colon cancer by inhibiting Wnt/β-catenin pathway via down-regulating miR-130a
β-catenin/ZEB1↓,
miR-130a↓,

4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
miR-497↑, Curcumin was found to cause the upregulation of miR-497, miR-200c, miR-200b, miR-409-3p, miR‐34, miR‐126, miR-145, miR-206, miR-491, miR-141, miR-429, miR-101, and miR-15a
miR-200c↑,
miR-409-3p↑,
miR-34a↑,
miR-126↑,
miR-145↑,
miR-206↑,
miR-491↑,
miR-141↑,
miR-429↑,
miR-101↑,
miR-15↑,
miR-21↓, and the downregulation of miR-21, miR-155, miR‐221, miR‐222, miR-17-5p, miR-130a, miR-27, and miR-20a.
miR-155↓,
miR-221↓,
miR‐222↓,
miR-17↓,
miR-130a↓,
miR-27a-3p↓,
miR-20↓,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Casp10∅, 1,   Casp8∅, 1,   DR4∅, 1,   DR5∅, 1,   FADD∅, 1,   miR-497↑, 1,  

Transcription & Epigenetics ⓘ

miR-145↑, 1,   miR-192-5p↑, 1,   miR-21↓, 4,   miR-27a-3p↓, 1,   miR-409-3p↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4∅, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1∅, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

miR-101↑, 1,   miR-34a↑, 1,   miR-429↑, 1,   miR-99↑, 1,   NKD2↑, 1,   STAT↓, 1,   TCF↓, 1,   Wnt↓, 1,  

Migration ⓘ

miR-130a↓, 4,   miR-141↑, 1,   miR-155↓, 1,   miR-20↓, 1,   miR-200c↑, 1,   miR-206↑, 1,   miR-221↓, 1,   miR-491↑, 1,   miR‐222↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 3,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

miR-126↑, 1,   miR-15↑, 1,   miR-17↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6∅, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 45

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-130a, miR-130a microRNA
3 Curcumin
1 Boron
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:705  State#:%  Dir#:1
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