EIF4E Cancer Research Results

EIF4E, eukaryotic translation initiation factor 4E: Click to Expand ⟱
Source:
Type: protein
EIF4E: a protein that plays a crucial role in the regulation of protein synthesis, particularly in the translation of mRNAs involved in cell growth, proliferation, and survival.
EIF4E overexpressed in: breast, lung, colon, and prostate cancer.
Scientific Papers found: Click to Expand⟱
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, in the human primary cultured glioma cells borneol regulated HIF-1a expression via mTORC1/eIF4E pathway.
Apoptosis↑, The higher the concentration of borneol, the greater the apoptosis rate
mTORC1↓, HIF-1 α, mTORC1, eIF4E and Bcl-2 were treated with four different concentrations (10, 20, 40, 80 μg/ml) of borneol for 24 hours MRNA expression level showed a downward trend
EIF4E↓,
Bcl-2↓,
BAX↑, the expression of Bax and caspase-3 protein showed an upward trend,
Casp3↑,
ChemoSen↑, borneol can cooperate with chemotherapy drugs by activating ROS mediated oxidative damage.
ROS↑,

5662- BNL,  Rad,    Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- vitro+vivo, GBM, NA
RadioS↑, We found that borneol administration along with radiotherapy significantly inhibited the growth of primary glioma cells in vitro and in vivo.
Beclin-1↑, coincided with increased expression of beclin-1 and LC3.
Hif1a↓, And the combination of borneol and radiation exposure significantly decreased the expression levels of HIF-1α, mTORC1 and eIF4E.
mTORC1↓,
EIF4E↓,
TumAuto↑, Our findings suggest that borneol sensitizes glioma cells to radiation by inducing autophagy via inhibition of the mTORC1/eIF4E/HIF-1α regulatory axis.

5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Borneol is a multifaceted anticancer agent with intrinsic cytotoxic activity;
Apoptosis↑, via diverse mechanisms such as apoptosis induction, mitochondrial dysfunction, ROS generation
mtDam↑,
ROS↑,
mTORC1↓, and inhibition of oncogenic pathways, including mTORC1/eIF4E/HIF-1α, NF-κB, STAT3, and PI3K/Akt.
EIF4E↓,
Hif1a↓,
NF-kB↓,
STAT3↓,
PI3K↓,
Akt↓,
ChemoSen↑, borneol demonstrates significant synergistic effects when combined with established chemotherapeutic agents like temozolomide, doxorubicin, cisplatin, paclitaxel, and 5-fluorouracil,
BioEnh↑, enhancing drug uptake, overcoming resistance, and amplifying apoptosis, especially in drug-resistant and brain tumor models.
BioAv↑, borneol possesses high intestinal absorption, BBB permeability, moderate toxicity, and compliance with Lipinski's Rule of Five.
BBB↑,
toxicity↝,

452- CUR,    Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells
- vitro+vivo, HNSCC, SCC9 - vitro+vivo, HNSCC, FaDu - vitro+vivo, HNSCC, HaCaT
TumCCA↑, arrested cell cycle at phase G2 /M
PI3k/Akt/mTOR↓,
Casp3↑,
EGFR↓, 0.18 fold
EGF↑, Curcumin induced a noticeable increase in the expression of EGF (11.3-fold change)
PRKCG↑, 13.2 fold
p‑Akt↓,
p‑mTOR↓,
RPS6KA1↓, 0.17 fold
EIF4E↓, 0.18 fold
proCasp3↓,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

EGF↑, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

PI3k/Akt/mTOR↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   proCasp3↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EIF4E↓, 4,   p‑mTOR↓, 1,   mTORC1↓, 3,   PI3K↓, 1,   PRKCG↑, 1,   RPS6KA1↓, 1,   STAT3↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↓, 3,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 2,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   toxicity↝, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EIF4E, eukaryotic translation initiation factor 4E
3 borneol
1 Radiotherapy/Radiation
1 Curcumin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:716  State#:%  Dir#:1
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