ATG5 Cancer Research Results

ATG5, Autophagy-related 5: Click to Expand ⟱
Source:
Type:
ATG5 (Autophagy-related 5) is a protein that plays a crucial role in the process of autophagy, a cellular mechanism that involves the degradation and recycling of damaged or dysfunctional cellular components. ATG5 is a key component of the autophagy machinery and is involved in the formation of autophagosomes, which are double-membraned vesicles that engulf and digest cellular components.
Increased expression in: breast, GBM (poor prognosis).
Decreased in: Colon, Prostate (associated with improved prognosis).
Scientific Papers found: Click to Expand⟱
7511- FA,    The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, CaSki
MMP9↓, FA inhibited cell invasion through reducing MMP-9 mRNA expression.
TumCCA↑, FA induced arrest in G0/G1 phase of the cell cycle in Hela and Caski cells with dose dependent (P < 0.05).
P53↑, FA induced the cell cycle-related proteins expression such as p53 and p21, and reduced Cyclin D1 and Cyclin E levels.
P21↑,
cycD1/CCND1↓,
cycE/CCNE↓,
LC3II↓, FA decreased the autophagy-related proteins such as LC3-II, Beclin1 and Atg12-Atg5 in a dose-dependent manner.
Beclin-1↓,
ATG5↓,
TumCP↓, FA can significantly inhibit cell proliferation and invasion in Hela and Caski cells
TumCI↓, FA inhibited cell invasion
MMP9↓, FA inhibited the cell invasion in Hela and Caski cervical cancer cells through reducing the expression of MMP-9

4729- Se,    Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilers
*ROS↓, Studies have reported that selenium (Se), which is one of the essential trace elements of the poultry and participates in the oxidative metabolism, can alleviate Cr(Ⅵ)-induced organ damage by inhibiting oxidative stress,
*NRF2↑, levels of Nrf2, glutathione peroxidase 1 (GPx-1), NAD(P)H: quinone oxidoreductase 1 (NQO1), and mechanistic target of rapamycin (mTOR) in the Se&Cr group was upregulated
*GPx1↑,
*NQO1↑,
*mTOR↑,
*Beclin-1↓, along with decreased expression of Beclin 1, ATG5 and LC3 compared to the Cr group.
*ATG5↓,
*LC3s↓,
*hepatoP↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   Beclin-1↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

MMP9↓, 2,   TumCI↓, 1,   TumCP↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   Beclin-1↓, 1,   LC3s↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: ATG5, Autophagy-related 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:723  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page