MCT1 Cancer Research Results

MCT1, Multiple Copies in T-cell malignancy 1: Click to Expand ⟱
Source:
Type:
MCT-1 is a transcriptional regulator that plays a crucial role in cell cycle regulation, apoptosis, and cell proliferation. Overexpression of MCT-1 has been observed in: Leukemia, Lymphoma, Breast, Lung, CRC.
Scientific Papers found: Click to Expand⟱
6023- CGA,    Pharmacological advances of the chlorogenic acids family: current insights and future research directions
- Review, AD, NA - Review, Park, NA - Review, IBD, NA
*Aβ↓, *neuroP↑, *cardioP↑, *GastroP↑, *RenoP↑, *hepatoP↑, *Obesity↓, *Bacteria↓, *BioAv↑, *BioAv↑, *BioAv↑, *ROS↓, *GutMicro↑, *IBI↑, *MCT1↓, *NF-kB↓, *DNMT1↓,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
GlucoseCon↓, lactateProd↓, ECAR↓, NO↓, ROS↑, HK2↓, PFK1↓, GAPDH↓, PKM2↓, LDHA↓, FASN↓, GLUT1↓, MCT1↓, MCT4↓, HCAR1↓, SDH↑, ChemoSen↑, ROS↑, BioAv↑, P53↑, NF-kB↓, pH↑,
466- CUR,    Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1
- in-vitro, Liver, HepG2 - in-vitro, Liver, HuT78
GlucoseCon↓, lactateProd↓, pH↑, NO↑, LAR↓, Hif1a↓, LDHA↓, MCT1↓, MDR1↓, STAT3↓, HCAR1↓,
1869- DCA,    Dichloroacetate induces autophagy in colorectal cancer cells and tumours
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29
LC3II↑, ROS↑, mTOR↓, MCT1↓, NADH:NAD↓, NAD↑, TumAuto↑, lactateProd↓, LDH↑,
6700- DFC,    Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments
- in-vitro, BC, MDA-MB-231
MCT1↓, MCT4↓, lactateProd↓,
6688- DFC,    New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
- in-vivo, lymphoma, U937
AntiCan↑, COX2↓, Myc↓, GLUT1↓, LDHA↓, MCT1↓, GlucoseCon↓, lactateProd↓, TumCP↓, other∅, toxicity↝,
6693- DFC,    New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells
- vitro+vivo, Var, NA
Myc↓, GLUT1↓, LDHA↓, MCT1↓, GlucoseCon↓, Glycolysis↓,
946- Nimb,    Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis
- in-vivo, NA, NA
Apoptosis↑, Bcl-2↓, P53↑, cl‑Casp3↑, Cyt‑c↑, ROS↑, SOD↓, Catalase↓, Glycolysis↓, GLUT3↓, LDHA↓, MCT1↓, NHE1↓, ATPase↓, CAIX↓,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   NADH↓, 1,   NRF2↑, 2,   OXPHOS↓, 1,   ROS↑, 5,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ETC↓, 1,   MMP↓, 1,   SDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   CAIX↓, 1,   ECAR↓, 1,   FASN↓, 2,   G6PD↓, 1,   GAPDH↓, 1,   GLS↓, 1,   GlucoseCon↓, 5,   Glycolysis↓, 3,   HK2↓, 2,   lactateProd↓, 5,   lactateProd↑, 1,   LAR↓, 1,   LDH↑, 1,   LDHA↓, 6,   MCT4↓, 2,   NAD↑, 1,   NADH:NAD↓, 1,   PDK1↓, 1,   PFK1↓, 1,   PKM2↓, 2,   SCD1↓, 1,   SREBP2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 3,   Bcl-2↓, 1,   Casp↑, 1,   cl‑Casp3↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   MCT1↓, 8,   Myc↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other∅, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMTs↓, 1,   P53↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   mTOR↓, 2,   STAT3↓, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   ATPase↓, 1,   MMPs↓, 1,   TumCI↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 2,   NO↓, 1,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 4,   GLUT3↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   HCAR1↓, 2,   Imm↑, 1,   NF-kB↓, 2,   NK cell↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   MDR1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   LDH↑, 1,   Myc↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   toxicity↝, 1,  
Total Targets: 89

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 2,  

Cell Death(tgid=5) ⓘ

MCT1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   Obesity↓, 1,   RenoP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: MCT1, Multiple Copies in T-cell malignancy 1
3 Curcumin
3 Diclofenac
1 Chlorogenic acid
1 Dichloroacetate
1 Nimbolide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:743  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page