VGCC Cancer Research Results

VGCC, Voltage-gated calcium channels: Click to Expand ⟱
Source:
Type: transmembrane proteins
VGCCs play a crucial role in various cellular processes, including cell signaling, proliferation, and differentiation.
VGCCs are transmembrane proteins that regulate the influx of calcium ions into cells. Calcium ions act as a second messenger, triggering various signaling pathways that control cell growth, survival, and migration. In cancer cells, VGCCs can be overexpressed or mutated, leading to aberrant calcium signaling and contributing to tumor growth and metastasis.
Overexpressed in: breast cancer, prostate cancer, colorectal cancer, glioblastoma Associated with: tumor growth, metastasis, and poor prognosis.
Scientific Papers found: Click to Expand⟱
5525- EP,    Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs)
- Review, Var, NA
CellMemb↑, Over 30 years ago, electric fields were shown to transiently permeabilize plasma membranes and to introduce deoxyribonucleic acid (DNA) into cells by electroporation.
Ca+2↑, NsPEFs have been shown to breach intracellular granules,9 to mobilize Ca2+ from the ER and through plasma membranes,18–20 and to modulate intracellular Ca2+ levels in chromaffin cells
ER Stress↑,
ROS↑, NsPEFs induce calcium-dependent reactive oxygen species, which appear to require calcium entry through the plasma membrane pores.
MMP↓, NsPEFs also cause a rapid time- and electric field-dependent dissipation of the mitochondria membrane potential (∆Ψm).
VGCC↓, It has been shown that nsPEFs inhibit voltage-gated Na+ and Ca2+ channels,35
VGSC↓,
Dose↝, What seems clear is that when used at low repetition rates (1–2 Hz), nsPEF-induced cell death is not thermal nor immediate, but somewhat calculated and finally, default-driven.

3952- Taur,    Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
- Review, AD, NA - Review, Stroke, NA
*antiOx↑, Taurine has antioxidative, osmoregulatory, and anti-inflammatory functions, among other cytoprotective properties.
*Inflam↓,
*Ca+2↓, Taurine intracellular effects are directed toward calcium homeostatic pathway, reducing calcium overload and thus preventing excitotoxicity, mitochondrial stress, and apoptosis.
*neuroP↑, significant relationship between taurine and astrocytes, as well as its homeostatic and neuroprotective role in the nervous system.
*other↑, taurine has been proposed as a novel therapeutic agent for many human diseases including stroke, epilepsy, neurodegenerative diseases like Alzheimer’s disease (AD)
*Dose↝, concentration declines with age, with decreasing values that range from 4–20 μmol/g during development to 1–9 μmol/g at adulthood
*PKCδ↓, taurine’s inhibitory effect on the protein kinase C (PKC), thereby blocking the phosphorylation and activation of voltage-gated calcium channels (VGCC), and therefore, decreasing calcium influx
*VGCC↓,
*GABA↑, may have a similar effect as GABAB receptors, so that its activation by taurine may lead to the activation of coupled inhibitory G-proteins,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

VGCC↓, 1,   VGSC↓, 1,  

Migration ⓘ

Ca+2↑, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

VGCC↓, 1,  

Migration ⓘ

Ca+2↓, 1,   PKCδ↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

GABA↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: VGCC, Voltage-gated calcium channels
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:758  State#:%  Dir#:1
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