cAMP Cancer Research Results

cAMP, cyclic adenosine monophosphate: Click to Expand ⟱
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Type:
cAMP (cyclic adenosine monophosphate) is a secondary messenger molecule that plays a crucial role in various cellular processes, including cell signaling, metabolism, and gene expression. In the context of cancer, cAMP has been found to have both tumor-promoting and tumor-suppressing effects.
Scientific Papers found: Click to Expand⟱
4928- PEITC,    Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
- vitro+vivo, Colon, SW-620
Risk↓, Dietary intake of bioactive phytochemicals including the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC) can reduce risk of human cancers, but possible epigenetic mechanisms of these effects are yet unknown.
HDAC↓, Sustained PEITC exposure not only blocked HDAC binding to euchromatin but was also associated with hypomethylation of PcG target genes that are typically hypermethylated in cancer.
TumW↓, The mean weight of tumors generated by SW620-PEITC cells was 63.6% of that generated by SW620-CON cells assessed at the same time point
TumCG↓, indicating that long-term exposure to low concentration of PEITC can potently restrict tumor growth in vivo.
AP-1↓, Unlike SW620-CON cells, tumor cells treated with PEITC displayed impaired signaling via AP-1 (activator protein 1), CRE/CREB (cAMP response elements), and NFkB pathways (Fig. 4c).
cAMP↓,
NF-kB↓,
BMI1↓, substantial down-regulation of PcG complex proteins including BMI-1 (B cell-specific Moloney murine leukemia virus integration site 1), SUZ12 (suppressor of zeste 12 homolog), EZH2 (enhancer of zeste homolog 2), Ring1A, and Ring1B.
SUZ12↓,
EZH2↓,
selectivity↑, ntriguingly, this PEITC-induced decrease in expression of PcG complex proteins was more pronounced in metastatic SW620 cells than in non-metastatic SW480 cells.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

cAMP↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

BMI1↓, 1,   HDAC↓, 1,   SUZ12↓, 1,   TumCG↓, 1,  

Migration ⓘ

AP-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,   SUZ12↓, 1,  

Functional Outcomes ⓘ

Risk↓, 1,   TumW↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cAMP, cyclic adenosine monophosphate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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