BMP2 Cancer Research Results

BMP2, Bone Morphogenetic Protein 2: Click to Expand ⟱
Source:
Type:
BMP2 (Bone Morphogenetic Protein 2) is a member of the TGF-β (Transforming Growth Factor-beta) superfamily, which plays a crucial role in regulating cell growth, differentiation, and apoptosis.
BMP2 is overexpressed in: Osteosarcoma, breast, lung, prostate cancers.
Scientific Papers found: Click to Expand⟱
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, apoptotic potential of myricetin is specific for affected cells. In healthy cells, it activates PI3K/Akt signaling and inhibits ERK/JNK pathway to induce cytoprotective influence
*Akt↑,
p‑Akt↓,
SIRT3↑,
p‑ERK↓,
p38↓,
VEGF↓,
MEK↓, MEK1
MKK4↓,
MMP9↓,
Raf↓,
F-actin↓,
MMP2↓,
COX2↓,
BMP2↓,
cycD1/CCND1↓,
Bax:Bcl2↑,
EMT↓,
EGFR↓,
TumAuto↑,

4931- PEITC,    Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Risk↓, The glucosinolate-derived PEITC has been widely documented to reduce the risk of prostate cancer by modulating multiple biologically relevant processes.
miR-194↑, PEITC treatment decreased miR-106a/b and miR-695 levels in LNCaP cells (Fig 1B), whereas miR-194 levels were up-regulated in both the LNCaP and the PC3 cells
TumCI↓, miR-194 suppresses PC3 cell invasiveness in vitro
MMP2↓, PEITC down-regulates MMP2 and MMP9 via miR-194
MMP9↓,
BMP2↓, We found that both miR-194 mimic and PEITC treatments decreased BMP1 expression
*chemoPv↑, In addition, growing evidence has suggested that epigenetic mechanisms, particularly those mediated by miRNAs, are implicated in the chemopreventive effects of PEITC


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MKK4↓, 1,   Raf↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Bax:Bcl2↑, 1,   BMP2↓, 2,   p38↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   p‑ERK↓, 1,   miR-194↑, 1,  

Migration ⓘ

F-actin↓, 1,   MMP2↓, 2,   MMP9↓, 2,   TumCI↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

Risk↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

Akt↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: BMP2, Bone Morphogenetic Protein 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:777  State#:%  Dir#:1
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