cytoP450 Cancer Research Results

cytoP450, cytochrome P450 (CYP): Click to Expand ⟱
Source:
Type:
Cytochrome P450 (CYP) enzymes are a large family of enzymes that play a crucial role in the metabolism of various substances, including drugs, environmental chemicals, and endogenous compounds. They are primarily found in the liver but are also present in other tissues.
Tumor Microenvironment: CYP enzymes can also be expressed in tumor tissues, where they may contribute to the local metabolism of drugs and other compounds, potentially affecting tumor growth and response to therapy.
Some CYPs may be upregulated, while others may be downregulated.
CYP1B1 is often overexpressed in breast, prostate, and lung cancers. This overexpression can contribute to the activation of procarcinogens and the metabolism of therapeutic agents, potentially influencing tumor growth and response to treatment.
CYP19A1 (aromatase) converts androgens to estrogens, and its expression can be associated with breast cancer progression.

Specific CYP enzymes, such as CYP1A1, CYP1B1, CYP17A1, and CYP19A1, have been associated with tumor progression and poor outcomes in various cancers.
Scientific Papers found: Click to Expand⟱
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Casp↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,  

DNA Damage & Repair ⓘ

DNMTs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   mTOR↓, 1,   PI3K↓, 1,   Wnt↓, 1,  

Migration ⓘ

MMPs↓, 1,   TumCI↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 1,   NF-kB↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSTs↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

cytoP450↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

radioP↑, 1,  
Total Targets: 16

Scientific Paper Hit Count for: cytoP450, cytochrome P450 (CYP)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:78  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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