Th2 Cancer Research Results

Th2, Type 2 helper cell: Click to Expand ⟱
Source:
Type:
Type 2 helper cell (Th2) pathway is a subset of the immune response that plays a crucial role in the regulation of inflammation, allergies, and parasitic infections.
Key cytokines involved in the Th2 pathway: IL-4, IL-13, IL-5, IL-9.

Elevated levels of certain Th2 cytokines (e.g., IL-10) can suppress cytotoxic T cell responses, thereby impairing effective antitumor immunity.

In several cancers (such as ovarian, gastric, and certain breast cancers), high levels of Th2 cytokines or an increased Th2 cell infiltration have been observed.
 - The relative balance between Th1 and Th2 responses is critical, with a Th2-skewed response often suggesting a shift away from effective cytotoxic antitumor immunity.

A predominant Th2 environment is frequently linked to worse prognostic features, including enhanced tumor progression, increased metastasis, and reduced overall survival in some cancer types.
Scientific Papers found: Click to Expand⟱
7926- H2,    Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model
- in-vivo, Asthma, NA
*Dose↝, Hydrogen gas was delivered to the mice through inhalation twice a day (2 h once) for 7 consecutive days
*Airway↓, Hydrogen gas inhalation significantly alleviated OVA-induced airway hyperresponsiveness, inflammation and goblet cell hyperplasia, diminished TH2 response and decreased IL-4 as well as IgE levels, reduced malondialdehyde (MDA) production
*BALF-Infl↓,
*Th2↓,
*IL4↓,
*IgE↓,
*MDA↓,
*SOD↑, increased superoxide dismutase (SOD) activity
*NF-kB↓, hydrogen gas inhalation inhibited NF-κB activation and markedly activated Nrf2 pathway in OVA-induced asthmatic mice.
*NRF2↑,

7940- TQ,    Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
- in-vivo, Asthma, NA
*Eos↓, TQ before airway challenge of ovalbumin (OVA)-sensitized mice resulted in a marked decrease in lung eosinophilia and the elevated Th2 cytokines observed after airway challenge with OVA antigen;
*Th2↓, TQ attenuates allergic airway inflammation by inhibiting Th2 cytokines and eosinophil infiltration into the airways; thus demonstrating its potential anti-inflammatory role during the allergic response in the lung.
*IgE↓, TQ also decreased the elevated serum levels of OVA-specific IgE and IgG1.
*IgG1↓,
*Inflam↓, TQ significantly inhibited allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells.
*AirwayM↓,
*IL4↓, While TQ showed a significant effect in inhibiting IL-4, IL-5 and IL-13 and some effect in inducing IFN-gamma production in the BAL fluid,
*IL5↓,
*IL13↓,
*IFN-γ↑,

7941- TQ,    Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma
- in-vivo, Asthma, NA
*5LO↓, Administration of TQ before OVA challenge inhibited 5-lipoxygenase, the main enzyme in leukotriene biosynthesis, expression by lung cells and significantly reduced the levels of LTB4 and LTC4.
*LTB4↓,
*LTC4↓,
*Th2↓, This was accompanied by a marked decrease in Th2 cytokines and BAL fluid and lung tissue eosinophilia, all of which are characteristics of airway inflammation.
*Eos↓,
*Inflam↓, These results demonstrate the anti-inflammatory effect of TQ in experimental asthma.


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 1,   AirwayM↓, 1,   BALF-Infl↓, 1,   Eos↓, 2,   IgE↓, 2,   IgG1↓, 1,   IL13↓, 1,   LTB4↓, 1,   LTC4↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

MDA↓, 1,   NRF2↑, 1,   SOD↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↑, 1,   IL4↓, 2,   IL5↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   Th2↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 20

Scientific Paper Hit Count for: Th2, Type 2 helper cell
2 Thymoquinone
1 Hydrogen Gas
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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