NCAM Cancer Research Results

NCAM, Neural Cell Adhesion Molecule: Click to Expand ⟱
Source:
Type:
NCAM (Neural Cell Adhesion Molecule) is a cell surface glycoprotein that plays a crucial role in cell-cell adhesion, migration, and signaling.
NCAM expression has been linked to increased tumor aggressiveness and poor prognosis in various cancer types, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, Berberine attenuated cancer stemness markers CD133, β-catenin, n-myc, sox2, notch2 and nestin.
CD133↓,
β-catenin/ZEB1↓,
n-MYC↓,
SOX2↓,
NOTCH2↓,
Nestin↓,
TumCCA↑, Berberine potentiated G0/G1 cell cycle arrest by inhibiting proliferation, cyclin dependent kinases and cyclins resulting in apoptosis through increased bax/bcl-2 ratio.
TumCP↓,
CDK1↓,
Cyc↓,
Apoptosis↑,
Bax:Bcl2↑,
NCAM↓, The induction of NCAM and reduction in its polysialylation indicates anti-migratory potential which is supported by down regulation of MMP-2/9.
MMP2↓,
MMP9↓,
*Smad1↑, It increased epithelial marker laminin and smad and increased Hsp70 levels also suggest its protective role.
*HSP70/HSPA5↑,
*LAMs↑,

5709- Brut,    Mechanisms Underlying the Anti-Tumoral Effects of Citrus bergamia Juice
- in-vitro, neuroblastoma, SH-SY5Y
TumCG↓, Here we show that BJ reduced growth rate of different cancer cell lines, with the maximal growth inhibition observed in neuroblastoma cells (SH-SY5Y) after 72 hs of exposure to 5% BJ.
TumCCA↑, BJ stimulated the arrest in the G1 phase of cell cycle
FAK↓, a reduction in the expression of the active form of focal adhesion kinase (FAK) that in turn caused inhibition of cell migration
TumCMig↓,
Dose↝, eriocitrin ([M-H]- 595 (287)), neoeriocitrin ([M-H]- 595), narirutin ([M-H]- 595 (271)), naringin ([M-H]- 595), neohesperidin ([M-H]- 609), naringin-di-oxalate ([M-H]- 621 (579)) neohesperidin-di-oxalate
NCAM↓, BJ Inhibits FAK Phosphorylation via Inhibition of NCAM Activity and Decrease of their Association


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   Cyc↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CSCs↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH2↓, 1,   SOX2↓, 1,   TumCG↓, 1,  

Migration ⓘ

FAK↓, 1,   MMP2↓, 1,   MMP9↓, 1,   NCAM↓, 2,   TumCMig↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Migration ⓘ

LAMs↑, 1,   Smad1↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: NCAM, Neural Cell Adhesion Molecule
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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