BioAv Cancer Research Results

BioAv, bioavailability: Click to Expand ⟱
Source:
Type: measurement
Bioavailability (usually in %) absorbed by the body.
Scientific Papers found: Click to Expand⟱
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,
5464- AF,    Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies
- vitro+vivo, GBM, NA
TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5439- AG,    Absorption enhancement study of astragaloside IV based on its transport mechanism in Caco-2 cells
- in-vitro, Colon, Caco-2
BioAv↑, BioAv↓,
4600- AgNPs,    Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model
- in-vivo, Nor, NA
*Half-Life↝, *toxicity↓, *Dose↑, *other↝, *eff↝, *BioAv↓,
4598- AgNPs,    In vivo human time-exposure study of orally dosed commercial silver nanoparticles
- in-vivo, Nor, NA
*toxicity∅, *Dose↝, *Dose↝, *BioAv↝, *BioAv↝, *H2O2∅, *IL8∅, *IL1α∅, *IL1β∅, *MCP1∅, *NQO1∅, *BioAv↓,
4594- AgNPs,  Citrate,    Bioavailability and Toxicokinetics of citrate-coated silver nanoparticles in rats
- in-vivo, Nor, NA
*BioAv↓,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
5165- AL,    The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects
- in-vitro, AML, Jurkat - in-vitro, Nor, L929
necrosis↑, Thiols↓, GSH↓, ENO1↓, Zn2+↑, Glycolysis↓, ATP↓, BioAv↓,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27↑, PDH↑, Glycolysis↓, ROS↑, *eff↑, *memory↑, *motorD↑, *GutMicro↑,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, eff↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
1554- Api,    A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota
- Review, NA, NA
*BioAv↑, *BioAv↑, *BioAv↑, *BioAv↓, *eff↑,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
1537- Api,    Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer
- Review, PC, NA
TumCP↓, TumCCA↑, Apoptosis↑, MMPs↓, Akt↓, *BioAv↑, *BioAv↓, Half-Life∅, Hif1a↓, GLUT1↓, VEGF↓, ChemoSen↑, ROS↑, Bcl-2↓, Bcl-xL↓, BAX↑, BIM↑,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
3387- ART/DHA,    Ferroptosis: A New Research Direction of Artemisinin and Its Derivatives in Anti-Cancer Treatment
- Review, Var, NA
BioAv↓, lipid-P↑, Ferroptosis↑, Iron↑, GPx4↓, GSH↓, P53↑, ER Stress↑, PERK↑, ATF4↑, GRP78/BiP↑, CHOP↑, ROS↑, NRF2↑,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
557- ART/DHA,    Artemisinin and Its Derivatives in Cancer Care
- Review, Var, NA
*BioAv↓, *BioAv↑, Apoptosis↑, EGFR↓, CD31↓, Ki-67↓, P53↓, TfR1/CD71↑, P-gp↓, PD-1↝,
2570- ART/DHA,    Discovery, mechanisms of action and combination therapy of artemisinin
- Review, Nor, NA
*BioAv↓, *Half-Life↓, *toxicity↓, *ROS↑, GSH↓, selectivity↑,
5394- Ash,    Safety and pharmacokinetics of Withaferin-A in advanced stage high grade osteosarcoma: A phase I trial
- Trial, OS, NA
toxicity↝, hepatoP↓, BioAv↓, Apoptosis↑, ROS↑, TumCCA↑,
3154- Ash,    Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts – A double blind, crossover study in healthy adults
BioAv↑, BioAv↓,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
5387- AsP,  PacT,    Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy
- in-vivo, Melanoma, B16-F10
Dose↝, TumCG↓, TumCP↓, BioAv↓, BioAv↑, other↑, Apoptosis↑, Bax:Bcl2↑, EPR↑, toxicity↝,
4807- ASTX,    An overview of the anticancer activity of astaxanthin and the associated cellular and molecular mechanisms
- Review, Var, NA
*antiOx↑, *neuroP↑, AntiCan↑, TumCG↓, TumCD↑, TumCMig↓, ChemoSen↑, chemoP↑, *BioAv↓, TumCP↓, TumCCA↑, Apoptosis↑, BioAv↑,
5417- ASTX,    Comparative Pharmacokinetic Study of Standard Astaxanthin and its Micellar Formulation in Healthy Male Volunteers
- Study, Nor, NA
*antiOx↑, *BioAv↓, *Dose↝, *BioAv↑,
5422- ASTX,    Improved intestinal absorption and oral bioavailability of astaxanthin using poly (ethylene glycol)-graft-chitosan nanoparticles: preparation, in vitro evaluation, and pharmacokinetics in rats
- in-vivo, Nor, NA
*antiOx↑, *AntiDiabetic↑, *toxicity∅, *BioAv↓, *BioAv↑,
5423- ASTX,    Pharmacokinetic Profile of Astaxanthin Nanoemulsion Using HPLC (High-Performance Liquid Chromatography) With Oral Routes
- in-vivo, Nor, NA
*BioAv↓, *antiOx↑, *BioAv↑, *Half-Life↝,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
5445- ATV,    Atorvastatin
- NA, Nor, NA
*cardioP↑, *LDL↓, HMG-CoA↓, Half-Life↝, BioAv↓, Dose↝,
5572- B-Gluc,    The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study
- Study, Nor, NA
Imm↑, *Dose↝, *BioAv↓, *toxicity↑,
5570- B-Gluc,    Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1
- Review, Var, NA
Imm↑, BioAv↝, eff↑, AntiCan↑, Dectin1↝, Dose↝, BioAv↓,
5566- B-Gluc,    The effects of beta-glucan on human immune and cancer cells
- Review, Var, NA
Imm↑, *BioAv↓, OS↑, ChemoSen↑,
5497- Ba,    Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics
- Review, Var, NA
*Inflam↓, AntiCan↑, BioAv↝, BioAv⇅, BioAv↓, CYP3A2↓, P-gp↓,
5496- Ba,    A strategy to improve the oral availability of baicalein: The baicalein-theophylline cocrystal
- in-vivo, Nor, NA
*BioAv↓, *BioAv↑,
5249- Ba,  BA,    Baicalein and baicalin in cancer therapy: Multifaceted mechanisms, preclinical evidence, and translational challenges
- Review, Var, NA
Apoptosis↑, Inflam↓, TumCCA↑, ChemoSen↑, RadioS↑, TumCG↓, toxicity↓, BioAv↓, Half-Life↓,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
4304- Ba,    Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
- in-vitro, AD, NA
*tau↓, *Dose↝, *BioAv↓,
2603- Ba,    Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, Apoptosis↑, Cav1↓, p‑Akt↓, p‑mTOR↓, Bax:Bcl2↑, survivin↓, cl‑PARP↑, BioAv↓,
2597- Ba,    Baicalein – An Intriguing Therapeutic Phytochemical in Pancreatic Cancer
- Review, PC, NA
chemoP↑, ChemoSen↑, 12LOX?, Bcl-2↓, BAX↑, Mcl-1↓, ERK↓, Prx6↑, Dose↝, BioAv↓, eff↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
5543- BBM,    Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo
- in-vivo, Lung, B16-F10 - vitro+vivo, Lung, A549 - in-vitro, BC, MDA-MB-231
BioAv↓, Half-Life↓, eff↑, TumMeta↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, MMP2↓, MMP9↓, VEGF↓, Bcl-2↓, eff↑, EPR↑,
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, NA, NA
*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, eff↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2670- BBR,    Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases
- Review, Var, NA
*Inflam↓, *antiOx↑, *Ca+2↓, *BioAv↓, *BioAv↑, *BioAv↑, *angioG↑, *MAPK↓, *AMPK↓, *NF-kB↓, VEGF↓, PI3K↓, Akt↓, MMP2↓, Bcl-2↓, ERK↓,
2671- BBR,    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- in-vivo, Diabetic, NA
*BioAv↓, *Half-Life↝, *OCR↓, *AMPK↑,
2673- BBR,    Therapeutic potential and recent delivery systems of berberine: A wonder molecule
- Review, Var, NA
*BioAv↓, *Half-Life↓, *neuroP↑, BBB↑, toxicity↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,

Showing Research Papers: 1 to 50 of 224
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 224

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 3,   frataxin↑, 1,   GPx↓, 1,   GPx4↓, 2,   GSH↓, 4,   Iron↑, 1,   c-Iron↑, 1,   lipid-P↑, 2,   NRF2↓, 2,   NRF2↑, 2,   OXPHOS↓, 1,   Prx6↑, 1,   ROS↓, 2,   ROS↑, 14,   Thiols↓, 1,   TrxR↓, 1,  

Metal & Cofactor Biology ⓘ

TfR1/CD71↑, 1,   Zn2+↑, 1,  

Mitochondria & Bioenergetics ⓘ

ADP:ATP↑, 1,   ATP↓, 2,   BCR-ABL↓, 1,   CDC2↓, 1,   CDC25↓, 3,   MMP↓, 2,   Mortalin↓, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX?, 1,   12LOX↓, 1,   ACSL4↑, 1,   AMPK↑, 2,   AMPK↝, 1,   Cav1↓, 1,   cMyc↓, 2,   CYP3A2↓, 1,   CYP3A4↓, 1,   ENO1↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   HK2↓, 1,   HMG-CoA↓, 1,   LDL↓, 1,   NADPH↓, 1,   PDH↑, 1,   PKM2↓, 2,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 10,   p‑Akt↓, 3,   Apoptosis↑, 13,   BAX↑, 7,   Bax:Bcl2↑, 3,   Bcl-2↓, 7,   Bcl-xL↓, 4,   BIM↑, 1,   Casp↑, 1,   Casp3↓, 2,   Casp3↑, 3,   Casp8↑, 3,   Casp9↑, 5,   Cyt‑c↑, 4,   DR5↑, 2,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 3,   IAP1↓, 1,   JNK↓, 1,   MAPK↓, 3,   Mcl-1↓, 2,   MDM2↓, 2,   necrosis↑, 1,   p27↑, 2,   survivin↓, 4,   Telomerase↓, 2,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↓, 1,   ER Stress↑, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 2,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 2,   DNMT1↓, 1,   m-FAM72A↓, 1,   MGMT↓, 1,   P53↓, 1,   P53↑, 5,   cl‑PARP↑, 2,   PCNA↓, 1,   γH2AX↝, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   E2Fs↓, 1,   P21↑, 3,   RB1↑, 1,   Securin↓, 1,   TumCCA↓, 1,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State ⓘ

cMYB↓, 1,   CSCs↓, 1,   EMT↓, 6,   EMT↑, 1,   ERK↓, 5,   GSK‐3β↓, 3,   HDAC1↓, 1,   HDAC10↓, 1,   HDAC8↓, 1,   HMGCR↓, 1,   mTOR↓, 7,   mTOR↝, 1,   p‑mTOR↓, 2,   NOTCH1↓, 1,   PI3K↓, 7,   RAS↓, 1,   Shh↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 6,   TumCG↑, 1,   Wnt↓, 4,   Wnt/(β-catenin)↓, 1,   Zn2+↑, 1,  

Migration ⓘ

annexin II↓, 1,   AP-1↓, 2,   CD31↓, 1,   Cdc42↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   FAK↓, 2,   ITGB1↓, 1,   ITGB3↓, 1,   Ki-67↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 9,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 8,   MMPs↓, 3,   N-cadherin↓, 1,   PKCδ↓, 1,   Rho↓, 1,   ROCK1↓, 3,   Snail↓, 1,   TET1?, 1,   TGF-β↓, 1,   TIMP2↑, 1,   TumCI↓, 5,   TumCMig↓, 4,   TumCP↓, 8,   TumMeta↓, 5,   uPA↓, 2,   Vim↓, 4,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   ATF4↑, 1,   EGFR↓, 5,   EPR↑, 2,   Hif1a↓, 5,   LOX1↓, 1,   VEGF↓, 7,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 3,   P-gp↓, 4,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   COX2↓, 5,   COX2↑, 1,   CXCR4↓, 1,   Dectin1↝, 1,   p‑IKKα↓, 1,   IL1↓, 1,   IL12↑, 1,   IL1β↓, 1,   IL2↓, 1,   IL2↑, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 3,   p‑JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 7,   PD-1↝, 1,   PD-L1↓, 3,   PGE2↓, 2,   TNF-α↓, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 25,   BioAv↑, 8,   BioAv⇅, 1,   BioAv↝, 3,   ChemoSen↑, 16,   CYP1A2↓, 1,   CYP2C9↓, 1,   Dose↝, 4,   Dose∅, 2,   eff↓, 3,   eff↑, 17,   eff↝, 3,   Half-Life↓, 3,   Half-Life↝, 1,   Half-Life∅, 2,   MDR1↓, 1,   RadioS↑, 5,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 5,   GutMicro↑, 1,   IL6↓, 2,   Ki-67↓, 1,   PD-L1↓, 3,  

Functional Outcomes ⓘ

AntiCan↑, 7,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 4,   chemoPv↑, 1,   hepatoP↓, 1,   OS↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 3,   toxicity↝, 2,   TumVol↓, 1,  

Infection & Microbiome ⓘ

Dectin1↝, 1,   Sepsis↓, 1,  
Total Targets: 242

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx?, 1,   antiOx↑, 11,   Catalase↑, 1,   GPx↑, 2,   H2O2∅, 1,   lipid-P↓, 1,   MDA↓, 1,   NQO1∅, 1,   NRF2↑, 2,   ROS↓, 6,   ROS↑, 1,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↓, 1,   AMPK↑, 1,   cAMP↑, 1,   LDL↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Casp3↓, 1,   Casp9↓, 1,   iNOS↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↝, 1,  

DNA Damage & Repair ⓘ

DNArepair↑, 1,  

Migration ⓘ

Ca+2↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1α∅, 1,   IL1β↓, 1,   IL1β∅, 1,   IL2↓, 1,   IL6↓, 1,   IL8∅, 1,   INF-γ↓, 1,   Inflam↓, 7,   MCP1∅, 1,   NF-kB↓, 2,   PGE2↓, 1,   TLR2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

ChAT↑, 1,   tau↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 27,   BioAv↑, 13,   BioAv↝, 3,   ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 5,   eff↑, 3,   eff↝, 1,   Half-Life↓, 4,   Half-Life↝, 4,   Half-Life∅, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   cardioP↓, 1,   cardioP↑, 3,   cognitive↑, 4,   hepatoP↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 6,   RenoP↑, 1,   toxicity↓, 5,   toxicity↑, 1,   toxicity∅, 2,  
Total Targets: 71

Scientific Paper Hit Count for: BioAv, bioavailability
16 Curcumin
10 Resveratrol
9 Baicalein
7 Berberine
7 Betulinic acid
7 Thymoquinone
6 Propolis -bee glue
6 Silymarin (Milk Thistle) silibinin
6 Lycopene
6 Quercetin
5 Apigenin (mainly Parsley)
5 Biochanin A
5 Chlorogenic acid
5 Chrysin
5 Honokiol
5 Piperlongumine
4 Artemisinin
4 Astaxanthin
4 Capsaicin
4 EGCG (Epigallocatechin Gallate)
4 Ellagic acid
4 Fisetin
4 Luteolin
4 Shikonin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Ashwagandha(Withaferin A)
3 beta-glucans
3 borneol
3 Carvacrol
3 Celastrol
3 HydroxyTyrosol
3 Magnolol
3 Sulforaphane (mainly Broccoli)
3 Silicic Acid
3 Aflavin-3,3′-digallate
2 Astragalus
2 Allicin (mainly Garlic)
2 Atorvastatin
2 Baicalin
2 Boswellia (frankincense)
2 Caffeic acid
2 Camptothecin
2 Emodin
2 Ferulic acid
2 Hydroxycinnamic-acid
2 Rutin
2 Ursolic acid
2 Urolithin
1 3-bromopyruvate
1 Auranofin
1 Citric Acid
1 Chemotherapy
1 Ascorbyl Palmitate
1 Paclitaxel
1 Berbamine
1 Bacopa monnieri
1 Butyrate
1 urea
1 Thymol-Thymus vulgaris
1 Catechins
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 chitosan
1 Chlorophyllin
1 Chocolate
1 irinotecan
1 Disulfiram
1 Copper and Cu NanoParticles
1 Fenbendazole
1 Gallic acid
1 Gambogic Acid
1 Folic Acid, Vit B9
1 Magnetic Fields
1 magnetic nanoparticles
1 Naringin
1 Oleuropein
1 Oleocanthal
1 Phenethyl isothiocyanate
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 enzalutamide
1 Rosmarinic acid
1 salinomycin
1 Spermidine
1 Selenite (Sodium)
1 Tomatine
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:792  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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