APAF1 Cancer Research Results

APAF1, Apoptotic Protease Activating Factor 1: Click to Expand ⟱

Source:

Type: protein

APAF1 (Apoptotic Protease Activating Factor 1) is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death. APAF1 is a key component of the intrinsic pathway of apoptosis, which is activated in response to cellular stress or damage.
Downregulated in: breast, lung, prostate, colon (with poor prognosis)
APAF1 activators have been developed and are being tested in preclinical and clinical studies.

Scientific Papers found: Click to Expand⟱

3263-

Lyco,

Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

in-vitro,

Nor,

H9c2

in-vitro,

Stroke,

*Apoptosis↓, LP pretreatment significantly increased cell viability, reduced myocardial infarct size and decreased the apoptosis rate.
*MMP↑, decrease of ΔΨm were attenuated by LP and the expressions of cytochrome c, APAF-1, cleaved caspase-9 and cleaved caspase-3 were also decreased by LP
*Cyt‑c↓,
*APAF1↓,
*cl‑Casp9↓,
*cl‑Casp3↓,
*Bcl-2↑, LP treatment markedly increased Bcl-2 expression, decreased Bax expression and the Bax/Bcl-2 ratio.
*BAX↓,
cardioP↑, myocardial ischemia-reperfusion injury (MIRI). LP protects against MIRI by inhibiting MPTP opening, partly through the modulation of Bax and Bcl-2.

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Functional Outcomes ⓘ

cardioP↑, 1,
Total Targets: 1

Pathway results for Effect on Normal Cells:

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,

Cell Death ⓘ

APAF1↓, 1, Apoptosis↓, 1, BAX↓, 1, Bcl-2↑, 1, cl‑Casp3↓, 1, cl‑Casp9↓, 1, Cyt‑c↓, 1,
Total Targets: 8

Scientific Paper Hit Count for: APAF1, Apoptotic Protease Activating Factor 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells