Database Query Results : , , G6PD

G6PD, Glucose-6-phosphate dehydrogenase: Click to Expand ⟱
Source:
Type:
Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that plays a crucial role in the pentose phosphate pathway (PPP), a metabolic pathway that generates NADPH and pentoses from glucose-6-phosphate. G6PD is the first enzyme in the PPP and is responsible for catalyzing the conversion of glucose-6-phosphate to 6-phosphogluconate, producing NADPH in the process.
**** patients who receive intravenous ascorbate must be prescreened for glucose 6 phosphate dehydrogenase deficiency.

G6PD expression is often elevated in various cancers and is generally linked to poorer prognosis.
Scientific Papers found: Click to Expand⟱
1274- Cin,    Cinnamon bark extract suppresses metastatic dissemination of cancer cells through inhibition of glycolytic metabolism
- vitro+vivo, BC, MDA-MB-231
TumCI↓, G6PD↓, HK2↓, Glycolysis↓,
3276- Lyco,    Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma
- in-vivo, HCC, NA
G6PD↓, PCNA↓, cycD1↓, P21↑, Hif1a↓, Glycolysis↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,
2362- SK,    RIP1 and RIP3 contribute to shikonin-induced glycolysis suppression in glioma cells via increase of intracellular hydrogen peroxide
- in-vitro, GBM, U87MG - in-vivo, GBM, NA - in-vitro, GBM, U251
RIP1↑, RIP3↑, Glycolysis↓, G6PD↓, HK2↓, PKM2↓, H2O2↑, GSH↓, ROS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Results for Effect on Cancer/Diseased Cells:
AMPK↑,1,   cycD1↓,1,   ER Stress↑,1,   G6PD↓,4,   GlucoseCon↓,1,   GLUT1↓,1,   Glycolysis↓,4,   GRP78/BiP↑,1,   GSH↓,1,   H2O2↑,1,   Hif1a↓,2,   HK2↓,3,   LDH↓,1,   mTOR↓,1,   p‑NF-kB↓,1,   P21↑,1,   PCNA↓,1,   PDH↑,1,   PFK↓,1,   PFK1↓,1,   PI3K↓,1,   PKM2↓,2,   R5P↝,1,   RIP1↑,1,   RIP3↑,1,   ROS↑,2,   SIRT1↑,1,   SIRT3↑,1,   talin↓,1,   TKT↝,1,   TumCG↓,1,   TumCI↓,2,   TumCP↓,1,   Warburg↓,1,  
Total Targets: 34

Results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: G6PD, Glucose-6-phosphate dehydrogenase
1 Cinnamon
1 Lycopene
1 Resveratrol
1 Shikonin
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:808  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page