NAD Cancer Research Results

NAD, Nicotinamide adenine dinucleotide: Click to Expand ⟱
Source:
Type: coenzyme
NAD generally refers to the oxidized form, known as NAD⁺
NAD (Nicotinamide adenine dinucleotide) is a coenzyme that plays a crucial role in various cellular processes, including energy metabolism, DNA repair, and cell signaling. Research has shown that NAD levels are often decreased in cancer cells, and this decrease can contribute to the development and progression of cancer.
NAD is a coenzyme that plays a central role in energy metabolism, DNA repair, and cell signaling. It exists in two forms: NAD+ (oxidized) and NADH (reduced).

NADH is the reduced form of NAD⁺. When NAD⁺ accepts electrons (typically during metabolic processes like glycolysis, the citric acid cycle, and beta-oxidation), it becomes NADH.

NADPH, on the other hand, is a phosphorylated form of NADP+, which is a related coenzyme. NADPH is primarily involved in anabolic reactions, such as fatty acid synthesis, cholesterol synthesis, and antioxidant defenses.
Scientific Papers found: Click to Expand⟱
3454- ALA,    Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,
710- Bor,    Boric acid inhibits stored Ca2+ release in DU-145 prostate cancer cells
- in-vitro, Pca, DU145
NAD↓, TumCP↓, CD38↑, Ca+2↓,
4468- VitC,  SSE,    Selenium modulates cancer cell response to pharmacologic ascorbate
- in-vivo, GBM, U87MG - in-vitro, CRC, HCT116
eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,
633- VitC,    Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
- Analysis, NA, NA
Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,
630- VitC,    Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress
- in-vitro, BC, MCF-7 - in-vitro, BC, HT-29
TCA↑, ATP↓, NAD↓, H2O2↑, GSH/GSSG↓,
629- VitC,  Cu,  Fe,    The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer
- in-vitro, NA, NA
ROS↑, DNAdam↑, NAD↓,
628- VitC,  Mg,    Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
- in-vivo, Colon, CT26 - in-vitro, NA, MCF-7 - in-vitro, NA, SkBr3
AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 2,   GSH/GSSG↓, 1,   H2O2↑, 2,   lipid-P↑, 1,   ROS↑, 4,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 3,   mitResp↓, 1,   MMP↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   NAD↓, 7,   PFK↓, 1,   TCA↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   proCasp3↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Autophagy & Lysosomes ⓘ

LC3B-II↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 4,   PARP↑, 2,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD24↓, 1,   CD44↓, 1,   CSCs↓, 1,   EMT↓, 1,   mTOR↓, 1,   TumCG↑, 1,  

Migration ⓘ

Ca+2↓, 1,   CD38↑, 1,   TumCP↓, 1,  

Barriers & Transport ⓘ

SVCT-2↝, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 3,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 44

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NAD, Nicotinamide adenine dinucleotide
5 Vitamin C (Ascorbic Acid)
1 Alpha-Lipoic-Acid
1 Boron
1 Selenite (Sodium)
1 Copper and Cu NanoParticles
1 Iron
1 Magnesium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:815  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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