AFP Cancer Research Results

AFP, α-fetal protein: Click to Expand ⟱
Source:
Type: biomarker
α-fetal protein (AFP) is a protein that is typically produced by the liver and yolk sac of a developing fetus. In adults, high levels of AFP in the blood can be a sign of certain types of cancer, particularly those of the liver, testes, and ovaries.

-AFP is primarily known as a serum biomarker in hepatocellular carcinoma (HCC), but its expression and prognostic significance can also extend to other malignancies.


Scientific Papers found: Click to Expand⟱
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5891- CAR,  SRF,    Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7
- in-vivo, HCC, NA
eff↑, OS↑, hepatoP↑, AFP↓, NOTCH↓, cycD1/CCND1↓, Bcl-xL↑, Casp3↑, TRPM7↓, Dose↝,
655- EGCG,    A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells
- in-vitro, HCC, HepG2
AFP↓, TumAuto↑, LC3II↑, TumCG↓, MMP↓,
5228- EMD,    Evaluating anticancer activity of emodin by enhancing antioxidant activities and affecting PKC/ADAMTS4 pathway in thioacetamide-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
OS↑, PKCδ↓, ERK5↓, MMP3↓, VEGF↓, NRF2↑, HO-1↑, MDA↓, AFP↓,
2489- metroC,  capec,    Long-lasting response with metronomic capecitabine in advanced hepatocellular carcinoma
- Case Report, HCC, NA
Dose↝, OS↑, TumVol↓, AFP↓,
2486- metroC,  capec,    Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases
- Case Report, HCC, NA
OS↑, eff↝, Dose↝, AFP↓, Dose↝, TumVol↓, AFP↓,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 2,   HO-1↑, 1,   MDA↓, 2,   MDA↑, 1,   NRF2↑, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   BAX↑, 2,   Bcl-2↓, 3,   Bcl-xL↑, 1,   Casp↑, 1,   Casp3↑, 3,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   FADD↑, 1,   Fas↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   p38↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   ERK5↓, 1,   mTOR↓, 1,   NOTCH↓, 1,   PI3K↓, 1,   TRPM7↓, 2,   TumCG↓, 1,  

Migration ⓘ

AXL↓, 1,   E-cadherin↑, 1,   F-actin↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 3,   ZEB2↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 1,   Dose↝, 5,   eff↑, 2,   eff↝, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AFP↓, 8,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   hepatoP↑, 2,   OS↑, 5,   TumVol↓, 2,   Weight↑, 1,  
Total Targets: 75

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 1,   GSR↑, 2,   lipid-P↓, 2,   SOD↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   LDH↓, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 2,   AST↓, 2,   LDH↓, 2,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: AFP, α-fetal protein
3 Carvacrol
2 metronomic chemo
2 capecitabine
1 Thymol-Thymus vulgaris
1 Sorafenib (brand name Nexavar)
1 EGCG (Epigallocatechin Gallate)
1 Emodin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:829  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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