Nrf1 Cancer Research Results

Nrf1, Nuclear factor erythroid 2-related factor 1: Click to Expand ⟱
Source:
Type: transcription factor
Nrf1 (Nuclear factor erythroid 2-related factor 1) is a transcription factor that plays a crucial role in regulating cellular responses to stress, including oxidative stress and proteotoxic stress. While Nrf1 is generally considered a tumor suppressor, its expression and activity can be altered in various types of cancer, leading to either oncogenic or tumor-suppressive effects.

NRF1, together with related factors like NRF2, contributes to the cellular defense against oxidative damage by regulating antioxidant gene expression.

– This role can be double-edged: while it protects normal cells from damage, in cancer cells, enhanced antioxidant capacity might foster resistance to therapeutic agents that rely on oxidative stress to kill tumor cells.
Scientific Papers found: Click to Expand⟱
7811- ISQ,    Isoquercitrin alleviates OGD/R-induced oxidative stress and impaired mitochondrial biogenesis in SH-SY5Y cells via the NRF1/TFAM pathway
- in-vitro, Stroke, SH-SY5Y
*neuroP↑, *ROS↓, *Nrf1↓, *TFAM↑,
942- UA,    Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling
- vitro+vivo, BC, MCF7 - in-vitro, BC, MDA-MB-231
Cav1↑, Glycolysis↓, cMyc↓, LDHA↓, Nrf1↓, PGC-1α↓, Sp1/3/4↑, TumCG↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Nrf1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cav1↑, 1,   cMyc↓, 1,   Glycolysis↓, 1,   LDHA↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Nrf1↓, 1,   ROS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

TFAM↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Nrf1, Nuclear factor erythroid 2-related factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:878  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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