PCAF Cancer Research Results

PCAF, p300/CBP-associated factor: Click to Expand ⟱
Source:
Type:
PCAF (p300/CBP-associated factor) is a histone acetyltransferase (HAT) that plays a crucial role in the regulation of gene expression.
Scientific Papers found: Click to Expand⟱
7091- GAR,    Garcinol-A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, Var, NA
antiOx↑, Garcinol action in cancer cells is based on its antioxidant and anti-inflammatory properties, but also on its potency to inhibit histone acetyltransferases (HATs).
Inflam↓,
HATs↓,
p300↓, Elevated levels of P300/CBP and PCAF have been reported in many malignancies.
CBP↓,
PCAF↓,
cycD1/CCND1↓, Garcinol decreased cyclin D1 and cyclin D3 expression, decreased STAT expression, and caused inhibition of the PI3K/AKT pathway, which is crucial for proliferation, invasion, and metastasis
STAT↓,
PI3K↓,
Akt↓,
TumCP↓,
TumCI↓,
TumMeta↓,
TumCCA↑, garcinol application resulted in cell cycle arrest and a marked decrease in cyclin-dependent kinase 2 (CDK2) and cyclin-dependent kinase 4 (CDK4) expression
CDK2↓,
CDK4↓,

7092- GAR,    Garcinol and Its Role in Chronic Diseases
- Review, Var, NA
antiOx↑, demonstrated to be anti-oxidant, anti-inflammatory and anti-cancer in nature.
Inflam↓,
AntiCan↑,
NF-kB↓, Garcinia indica has been found to be an effective inhibitor of several key regulatory pathways (e.g., NF-kB, STAT3 etc.) in cancer cells, thereby being able to control malignant growth of solid tumours in vivo.
STAT3↓,
antiNeop↑, Despite its high potential as an anti-neoplastic modulator of several cancer types such as head and neck cancer, breast cancer, hepatocellular carcinoma, prostate cancer, colon cancer etc.
5LO↓, ability of garcinol to bind and inhibit 5-lipoxygenase (5-Lox),
eff↑, . The addition of 10 % FBS (fetal bovine serum) to medium leads to approximately 10-fold decrease in IC 50 value of garcinol for HCT116 cell growth.
HATs↓, Garcinol has been demonstrated to inhibit HATs such as p300 and PCAF both in vitro and in vivo
p300↓,
PCAF↓,
miR-200c↑, Garcinol treatment has been shown to cause upregulation of several tumor suppressor miRNAs, of which miR-200c was found to target and downregulate Notch1 in pancreatic CSCs
NOTCH1↓,
CSCs↓,
COX2/PTGS2↓, garcinol has been shown to cause significant reduction in expression level of cyclooxygenase-2 (COX-2), cyclin D1, and vascular endothelial growth factor
cycD1/CCND1↓,
VEGF↓,
PI3K↓, via inhibition of the extracellular signal-regulated protein kinase 1/2, PI3K/Akt and Wnt/b-catenin
Akt↓,
Wnt↑,
β-catenin/ZEB1↓,
ROS↑, It could lead to accumulation of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress modulator GADD153
CHOP/DDIT3↑,
Bax:Bcl2↑, increased Bax2/Bcl-2 ratio, elevated tBid (truncated Bid), and caspase 8 in cancer cell.
Casp8↑,
FAK↓, garcinol can lead to inhibition of tyrosine phosphorylation of focal adhesion kinase (FAK),
*neuroP↑, garcinol being considered in development of therapeutics for neurodegenerative diseases such as Alzheimers’s, Parkinson’s to attenuate oxidative stress-induced neurotoxicity.
PCNA↓, Significant reduction in proliferating cell nuclear antigen (PCNA) index in ACF was also observed with gar- cinol treatment
*GSTs↑, Garcinol administration in such cases was also seen to enhance activities of liver glutathione S-transferase (GST) and quinone reductase (QR), which play an important role in detoxification process of body

796- GAR,    Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
- vitro+vivo, Pca, HeLa
HATs↓, potent inhibitor of histone acetyltransferases p300 (IC50 approximately 7 microm)
PCAF↓,
Apoptosis↑,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Casp8↑, 1,   CBP↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↓, 3,   PCAF↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   NOTCH1↓, 1,   p300↓, 2,   PI3K↓, 2,   STAT↓, 1,   STAT3↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   FAK↓, 1,   miR-200c↑, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 2,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 1,  
Total Targets: 36

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSTs↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: PCAF, p300/CBP-associated factor
3 Garcinol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:888  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page