mPGES-1 Cancer Research Results

mPGES-1, Microsomal prostaglandin E synthase-1: Click to Expand ⟱
Source:
Type:
Microsomal prostaglandin E synthase-1 (mPGES-1) is an enzyme involved in the production of prostaglandin E2 (PGE2), a pro-inflammatory mediator that plays a role in various physiological and pathological processes, including cancer.
Expression is high in cancers and associated with poor prognosis and lower OS.
Scientific Papers found: Click to Expand⟱
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓,
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,
7749- ISL,    Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
- in-vitro, GBM, U87MG
angioG↓, COX2/PTGS2↓, mPGES-1↓, CYP4A/CYP4A11/CYP4A22↓, FGF21↓, TGF-β↓, VEGF↓, miR-194↑, NEAT1↓,
3499- MFrot,  MF,    Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans
- in-vitro, Nor, HUVECs
*AntiAge↑, *AMPK↑, *mPGES-1↓, *Ca+2↑, *ER Stress↑, *OS↑, *ROS↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CYP4A/CYP4A11/CYP4A22↓, 1,   NEAT1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FGF21↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   CBP↓, 1,   iNOS↓, 1,   Mcl-1↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   HATs↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CycB/CCNB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

miR-194↑, 1,   mTOR↓, 1,   NOTCH↓, 1,   p300↓, 1,   PI3K↓, 1,   STAT↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

CDK4/6↓, 1,   MMP2↓, 2,   MMP3↓, 1,   MMP9↓, 2,   N-cadherin↓, 1,   TGF-β↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Twist↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   CXCR4↓, 2,   IL1↓, 1,   mPGES-1↓, 3,   NF-kB↓, 1,   PGE2↓, 2,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EZH2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   toxicity↓, 1,  
Total Targets: 46

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

mPGES-1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   OS↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: mPGES-1, Microsomal prostaglandin E synthase-1
2 Garcinol
1 Isoliquiritigenin
1 Magnetic Field Rotating
1 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:899  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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