HDAC11 Cancer Research Results

HDAC11, Histone Deacetylase 11: Click to Expand ⟱
Source:
Type:
HDAC11 (Histone Deacetylase 11) is a member of the histone deacetylase family, which plays a crucial role in regulating gene expression by modifying chromatin structure. HDAC11 has been implicated in various types of cancer, and its expression has been associated with cancer prognosis.
Prognostic significance:
• High HDAC11 expression: Associated with poor prognosis and increased risk of metastasis in breast, gastric, lung, and pancreatic cancers.
• Low HDAC11 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Scientific Papers found: Click to Expand⟱
827- GAR,    Garcinol Is an HDAC11 Inhibitor
- in-vitro, NA, NA
HDAC11↓, Garcinol is a potent HDAC11 inhibitor (HDAC11 IC50 ~5 μM in vitro HPLC assay and IC50 ~10 μM in cellular SHMT2 fatty acylation assay)

3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, When nuclear extracts were incubated with increasing doses of quercetin (25 and 50uM) they were found to inhibit the function of the DNMTs by 32% and 49% respectively, in comparison to untreated control
HDAC↓, quercetin (25 and 50 uM), they were found to inhibit the function of the HDACs by 47% and 62% in comparison to untreated control.
HMTs↓, quercetin (25 and 50 uM), were found to inhibit the function of the HMT H3K9 by 63% and 71%
DNMT3A↓, preferred binding of quercetin on DNMT3A and DNMT3B is within the substrate binding cavity and could competitively inhibit the protein
EZH2↓, Quercetin interacts with EZH2 and functions as an inhibitor
HDAC1↓, Quercetin was able to reduce the activity of class II HDACs significantly, with concomitant downregulation of HDAC1, HDAC2, HDAC6, HDAC7, and HDAC11 expression
HDAC2↓,
HDAC6↓,
HDAC11↓,
G9a↓, quercetin and this correlates well with the observed downregulation of G9A expression
TIMP3↑, Fig8: quercetin resulted in reduced promoter methylation of several TSGs (APC, CDH1, CDH13, DAPK1, FHIT, GSTP1, MGMT, MLH1, PTEN, RARB, RASSF1, SOC51, TIMP3, and VHL
PTEN↑,
SOCS1↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

EZH2↓, 1,  

DNA Damage & Repair ⓘ

DNMT3A↓, 1,   DNMTs↓, 1,   G9a↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC1↓, 1,   HDAC11↓, 2,   HDAC2↓, 1,   HDAC6↓, 1,   HMTs↓, 1,   PTEN↑, 1,  

Migration ⓘ

TIMP3↑, 1,  

Immune & Inflammatory Signaling ⓘ

SOCS1↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HDAC11, Histone Deacetylase 11
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:904  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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