Neut Cancer Research Results
Neut, neutrophils: Click to Expand ⟱
| Source: |
| Type: white blood cell |
Neutrophils are a type of white blood cell that plays a crucial role in the immune system. They are involved in the defense against infections and inflammation.
High levels of neutrophils in the tumor microenvironment have been linked to poor prognosis in various types of cancer, including breast, lung, and colon cancer.
Neutropenia is an abnormally low number of circulating neutrophils
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Scientific Papers found: Click to Expand⟱
*Macrophages↓,
*Neut↓,
*p‑NF-kB↓,
*p‑MAPK↓,
*p‑JNK↓,
*p‑ERK↓, ERK1/2
*DNAdam↓, Uncaria tomentosa reduced the neutropenia caused by chemotherapy and was also able to restore cellular DNA damage.
Neut↓, A greater reduction in the white blood cell (WBCs) and the neutrophil counts were observed in the Ca group along the treatment, differently from the UtCa group, which remained closely the reference values
eff↑, We concluded that Ut is an effective adjuvant treatment for breast cancer.
Imm↑, Uncaria tomentosa enables the stimulation of the immune system, increasing resistance to diseases
Dose↝, Treatment using a daily dose of 300 mg dry Ut extract was effective in reducing the main chemotherapy effect, which is neutropenia.
*Dose?, received inhalation of 67% high concentration of hydrogen gas for 60 min once a day for 7 consecutive days after OVA or PBS challenge respectively
*IL4↓, Increased level of IL-4, IL-13, TNF-α and CXCL15 in the BALF and IL-4 in the serum were decreased significantly after inhalation.
*IL13↓,
*TNF-α↓,
*CXCL15↓,
*SOD↑, Hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase
*MDA↓, and significantly attenuated the increased level of malondialdehyde and myeloperoxidase
*MPO↓,
*ROS↓, Hydrogen gas inhalation improves lung function and protects established airway inflammation in the allergic asthmatic mice model which may be associated with the inhibition of oxidative stress process.
*antiOx↑, therapeutic effects of molecular hydrogen on various diseases have been investigated regarding its antioxidation capability [4] and its anti-inflammation [5] and anti-apoptosis
*Inflam↓,
*Apoptosis↓,
*toxicity↓, it is sufficiently mild that it does not disturb metabolic oxidation-reduction reactions or ROS-mediated cell signalling. Thus, it may be a safe and effective antioxidant for pulmonary diseases
*Stroke↓, , accumulating evidence has demonstrated various types of diseases involving oxidative stress, including ischaemic heart disease [7], stroke [8], acute lung injury [9] and inflammatory bowel disease
*Airway↓, Hydrogen gas inhalation decreased lung resistance in the asthmatic mice model
*Neut↓, There was a significant increase in the number of total cells, neutrophils , eosinophils , lymphocytes . Hydrogen gas inhalation resulted in significant reduction in the number of total cells
*Eos↓,
*BALF-Lym↓,
*BALF-Infl↓, Hydrogen gas inhalation attenuated the elevated levels of inflammatory cytokines present in BALF from the asthmatic mouse model
*AirwayM↓, In our study, we found the hydrogen gas inhalation significantly alleviated the pathologic inflammation degree and mucus content in the lung tissue.
*ROS↓, It has been demonstrated that pterostilbene inhibits reactive oxygen species production in neutrophils in vitro
*Neut↓, Pterostilbene downregulated the number of neutrophils in arthritic rats.
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in-vitro, |
BC, |
4T1 |
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in-vivo, |
BC, |
4T1 |
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T-Cell↑, in tumor microenviroment
Neut↓,
Macrophages↓,
ROS↑, RCQ significantly increased reactive oxygen species
MMP↓, in cancer cells
other↓, alleviate immunosuppression of the tumor microenvironment to enhance the anti-tumor effect.
AntiTum↑, at least nearly 5 times higher than that of a single Res/Cur/Que = 1:1:0.5
TumVol↓, 35-47% tumor inhibition rate
Showing Research Papers: 1 to 5 of 5
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
ROS↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
MMP↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
other↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
Imm↑, 1, Macrophages↓, 1, Neut↓, 2, T-Cell↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
Dose↝, 1, eff↑, 1,
Functional Outcomes(tgid=23) ⓘ
AntiTum↑, 1, TumVol↓, 1,
Total Targets: 11
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
Airway↓, 1, AirwayM↓, 1, BALF-Infl↓, 1, BALF-Lym↓, 1, CXCL15↓, 1, Eos↓, 1, IL13↓, 1, Stroke↓, 1,
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 1, MDA↓, 1, MPO↓, 1, ROS↓, 2, SOD↑, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↓, 1, p‑JNK↓, 1, p‑MAPK↓, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↓, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
p‑ERK↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
IL4↓, 1, Inflam↓, 1, Macrophages↓, 1, Neut↓, 3, p‑NF-kB↓, 1, TNF-α↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
Dose?, 1,
Functional Outcomes(tgid=23) ⓘ
toxicity↓, 1,
Total Targets: 26
Scientific Paper Hit Count for: Neut, neutrophils
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:910 State#:% Dir#:1
wNotes=on sortOrder:rid,rpid
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