Neut Cancer Research Results

Neut, neutrophils: Click to Expand ⟱
Source:
Type: white blood cell
Neutrophils are a type of white blood cell that plays a crucial role in the immune system. They are involved in the defense against infections and inflammation.
High levels of neutrophils in the tumor microenvironment have been linked to poor prognosis in various types of cancer, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
1242- BBM,    Berbamine Exerts Anti-Inflammatory Effects via Inhibition of NF-κB and MAPK Signaling Pathways
- in-vivo, Nor, NA
*Macrophages↓,
*Neut↓,
*p‑NF-kB↓,
*p‑MAPK↓,
*p‑JNK↓,
*p‑ERK↓, ERK1/2

5916- Cats,  Chemo,    Uncaria tomentosa—Adjuvant Treatment for Breast Cancer: Clinical Trial
- Trial, BC, NA
*DNAdam↓, Uncaria tomentosa reduced the neutropenia caused by chemotherapy and was also able to restore cellular DNA damage.
Neut↓, A greater reduction in the white blood cell (WBCs) and the neutrophil counts were observed in the Ca group along the treatment, differently from the UtCa group, which remained closely the reference values
eff↑, We concluded that Ut is an effective adjuvant treatment for breast cancer.
Imm↑, Uncaria tomentosa enables the stimulation of the immune system, increasing resistance to diseases
Dose↝, Treatment using a daily dose of 300 mg dry Ut extract was effective in reducing the main chemotherapy effect, which is neutropenia.

3928- PTS,    The effects of pterostilbene on neutrophil activity in experimental model of arthritis
- in-vivo, Arthritis, NA
*ROS↓, It has been demonstrated that pterostilbene inhibits reactive oxygen species production in neutrophils in vitro
*Neut↓, Pterostilbene downregulated the number of neutrophils in arthritic rats.

871- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
T-Cell↑, in tumor microenviroment
Neut↓,
Macrophages↓,
ROS↑, RCQ significantly increased reactive oxygen species
MMP↓, in cancer cells
other↓, alleviate immunosuppression of the tumor microenvironment to enhance the anti-tumor effect.
AntiTum↑, at least nearly 5 times higher than that of a single Res/Cur/Que  = 1:1:0.5
TumVol↓, 35-47% tumor inhibition rate


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,   Macrophages↓, 1,   Neut↓, 2,   T-Cell↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   TumVol↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Cell Death ⓘ

p‑JNK↓, 1,   p‑MAPK↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,  

Immune & Inflammatory Signaling ⓘ

Macrophages↓, 1,   Neut↓, 2,   p‑NF-kB↓, 1,  
Total Targets: 8

Scientific Paper Hit Count for: Neut, neutrophils
1 Berbamine
1 Cat’s Claw
1 Chemotherapy
1 Pterostilbene
1 Resveratrol
1 Curcumin
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:910  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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