CXCR2 Cancer Research Results

CXCR2, CXCR2: Click to Expand ⟱
Source:
Type: chemokine receptor
CXCR2 is a chemokine receptor that plays a crucial role in the progression and metastasis of various types of cancer.
CXCR2 is often over expression and is associated with poor prognosis and increased risk of metastasis.
Several CXCR2 inhibitors, such as SB225002 and AZD5069, have been developed and are being evaluated in preclinical and clinical studies for their potential to treat various types of cancer.
Scientific Papers found: Click to Expand⟱
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↑, 1,   MDA↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 2,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-xL↓, 1,   BID↑, 1,   cl‑Casp↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   DR4↑, 2,   DR5↑, 1,   FADD↑, 1,   FasL↑, 1,   MAPK↓, 1,   Mcl-1↓, 1,   MOMP↑, 1,   survivin↓, 2,  

DNA Damage & Repair ⓘ

P53↑, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↑, 1,   PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 1,   Wnt↓, 2,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCP↓, 3,   TumMeta↓, 1,   TumMeta↑, 1,   uPA↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   EGFR↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CXCR2↓, 2,   CXCR4↓, 2,   ICAM-1↓, 1,   IKKα↓, 1,   JAK2↓, 1,   NF-kB↓, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 2,  
Total Targets: 56

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   NRF2↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: CXCR2, CXCR2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:921  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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