MCT4 Cancer Research Results

MCT4, Monocarboxylate Transporter 4: Click to Expand ⟱
Source:
Type:
MCT4 is a member of the monocarboxylate transporter family, which plays a crucial role in the transport of lactate, pyruvate, and other monocarboxylates across cell membranes. In cancer, MCT4 is often upregulated to support the increased demand for lactate and pyruvate, which are essential for cancer cell metabolism.

High expression of MCT4 is often associated with poor prognosis in various cancers, including breast, lung, colorectal, prostate, pancreatic, ovarian, and glioblastoma.
Scientific Papers found: Click to Expand⟱
2308- CUR,    Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma Cells
- in-vitro, Liver, HepG2
GlucoseCon↓, Curcumin obviated the hyperglycemia-induced modulations like elevated glucose consumption, lactate production, and extracellular acidification, and diminished nitric oxide and reactive oxygen species (ROS) production
lactateProd↓,
ECAR↓,
NO↓,
ROS↑, Curcumin favors the ROS production in HepG2 cells in normal as well as hyperglycemic conditions. ROS production was detected in cancer cells treated with curcumin, or doxorubicin, or their combinations in NG or HG medium for 24 h
HK2↓, HKII, PFK1, GAPDH, PKM2, LDH-A, IDH3A, and FASN. Metabolite transporters and receptors (GLUT-1, MCT-1, MCT-4, and HCAR-1) were also found upregulated in high glucose exposed HepG2 cells. Curcumin inhibited the elevated expression of these enzymes, tr
PFK1↓,
GAPDH↓,
PKM2↓,
LDHA↓,
FASN↓,
GLUT1↓, Curcumin treatment was able to significantly decrease the expression of GLUT1, HKII, and HIF-1α in HepG2 cells either incubated in NG or HG medium.
MCT1↓,
MCT4↓,
HCAR1↓,
SDH↑, Curcumin also uplifted the SDH expression, which was inhibited in high glucose condition
ChemoSen↑, Curcumin Prevents High Glucose-Induced Chemoresistance
ROS↑, Treatment of cells with doxorubicin in presence of curcumin was found to cooperatively augment the ROS level in cells of both NG and HG groups.
BioAv↑, Curcumin Favors Drug Accumulation in Cancer Cells
P53↑, An increased expression of p53 in curcumin-treated cells can be suggestive of susceptibility towards cytotoxic action of anticancer drugs
NF-kB↓, curcumin has therapeutic benefits in hyperglycemia-associated pathological manifestations and through NF-κB inhibition
pH↑, Curcumin treatment was found to resist the lowering of pH of culture supernatant both in NG as well in HG medium.

6700- DFC,    Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments
- in-vitro, BC, MDA-MB-231
MCT1↓, diclofenac, a structurally-unrelated MCT1 and MCT4 blocker (32), also abrogated the influx of lactate
MCT4↓,
lactateProd↓,

6703- DFC,    Molecular docking of anti-inflammatory drug diclofenac with metabolic targets: Potential applications in cancer therapeutics.
- Analysis, Var, NA
*Inflam?, NSAID diclofenac, 2-[2-(2,6-dichloroanilino)phenyl]acetic acid, which is conventionally used in clinical practice as a potent anti-inflammatory drug, owing to its proven safety records is also being tested for its antineoplastic potential
*COX1↓, anti-inflammatory action of diclofenac has been mainly attributed to its ability to inhibit prostaglandin-endoperoxide synthase-1 and 2 (PGES), commonly known as Cyclooxygenase-1 and 2
*COX2↓,
GLUT1↓, our results of docking analysis indicated optimum binding strength of diclofenac with targets in following order GLUT1, MCT4, LDH A, COX1, BCRP/ABCG2, HDM2/MDM2, COX2, MRP1, MnSOD/SOD2, Myc, β-Catenin, VEGF, IκB, c-Jun and E2F1.
MCT4↓,
LDHA↓,
ABCG2↓,
MDM2↓,
MRP1/ABCC1↓,
SOD2↓,
Myc↓,
β-catenin/ZEB1↓,
VEGF↓,
IKKα↓,
cJun↓,
E2Fs↓,

995- MEL,    Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
- vitro+vivo, GBM, NA
LDHA↓,
MCT4↓,
lactateProd↓,
i-pH↓, decrease in intracellular pH: melatonin treatment induced a pH reversal with intracellular acidosis parallel to a downregulation in glycolysis in GBM.
ROS↑,
ATP↓,
TumCD↑, cytotoxic effects on GBM were due, at least in part, to intracellular pH modulation
TumCCA↑, cell cycle arrest at G0/G1 in both GBM1A and QNS120 and G2/M in GBM1A
PDH↓, decrease in pyruvate dehydrogenase (PDH) expression for both cell lines at aMT 3.0 mM
Glycolysis↓,
GlucoseCon↓,
TumCG↓, in vivo

2621- Wog,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, Var, NA
Hif1a↓, Wogonin at 15 μg/ml reduces the expression of HIF-1α, and down-regulates the levels of MCT4 and LDH
MCT4↓,
LDH↓,
lactateProd↓, thereby reducing the production of lactic acid,
ECAR↓, improving the acidic microenvironment,
TumCP↓, inhibiting cellular proliferation
Glycolysis↓, Compounds such as wogonin inhibited glycolysis by suppressing HIF-1α


Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 3,   SOD2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   SDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ECAR↓, 2,   FASN↓, 1,   GAPDH↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 4,   LDH↓, 1,   LDHA↓, 3,   MCT4↓, 5,   PDH↓, 1,   PFK1↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

MCT1↓, 2,   MDM2↓, 1,   Myc↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HCAR1↓, 1,   IKKα↓, 1,   NF-kB↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   i-pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↑, 1,   ChemoSen↑, 1,   MRP1/ABCC1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,   Myc↓, 1,  
Total Targets: 43

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 1,   Inflam?, 1,  
Total Targets: 3

Scientific Paper Hit Count for: MCT4, Monocarboxylate Transporter 4
2 Diclofenac
1 Curcumin
1 Melatonin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:949  State#:%  Dir#:1
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