SREBF2 Cancer Research Results

SREBF2, Sterol Regulatory Element Binding Factor 2: Click to Expand ⟱
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The SREBF2 gene (Sterol Regulatory Element Binding Factor 2) is a key regulator of lipid metabolism, particularly in the synthesis of cholesterol and fatty acids. The SREBF2 gene is overexpressed in various types of cancer.

SREBF2 gene is a key regulator of lipid metabolism and is overexpressed in various types of cancer. Its expression is associated with poor prognosis and increased risk of metastasis and recurrence.
Scientific Papers found: Click to Expand⟱
1544- Api,    The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68
- in-vitro, Nor, WRL68
*SREBF2↓, apigenin prevented SREBP-2 translocation and reduced the downstream gene HMGCR transcription
*HMGCR↓,
*Dose∅, oral dosages of 5.4 mg apigenin/kg body weight would produce a C max value of 16.5 μm in serum
*BioAv?, Given its high bioavailability, its action on cholesterol synthesis could be achievable in this administrative method

1006- CUR,    The effect of Curcuma longa extract and its active component (curcumin) on gene expression profiles of lipid metabolism pathway in liver cancer cell line (HepG2)
- in-vitro, Liver, HepG2
TumCP↓,
PGC1A↑,
CPT1A↑,
ACOX1↑,
SCD1↓,
SREBF2↓,
DGAT1↓,

1320- EMD,  SRF,    Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7 - vitro+vivo, Hepat, SK-HEP-1
SREBF2↓,
Akt↓,
TumCCA↑, increased cell cycle arrest in the G1 phase
TumCG↓, combination of emodin and sorafenib was sufficient to inhibit tumor growth.
STAT3↓,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ACOX1↑, 1,   CPT1A↑, 1,   DGAT1↓, 1,   PGC1A↑, 1,   SCD1↓, 1,   SREBF2↓, 2,  

Cell Death ⓘ

Akt↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCP↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

SREBF2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HMGCR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv?, 1,   Dose∅, 1,  
Total Targets: 4

Scientific Paper Hit Count for: SREBF2, Sterol Regulatory Element Binding Factor 2
1 Apigenin (mainly Parsley)
1 Curcumin
1 Emodin
1 Sorafenib (brand name Nexavar)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:959  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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