EP2 Cancer Research Results

EP2, Prostaglandin E2 receptor 2: Click to Expand ⟱
Source:
Type:
Also known as PTGER2
EP2 (Prostaglandin E2 receptor 2) is a receptor that plays a role in various cellular processes, including inflammation and cell growth. In cancer, EP2 has been implicated in tumor development and progression.
Tumorigenic potential:
-promote tumorigenesis by enhancing cell proliferation and survival
-Increasing angiogenesis (formation of new blood vessels)
-Suppressing apoptosis (programmed cell death)
-Promoting invasion and metastasis

Expression levels in cancer:
Overexpressed in:Colorectal, Breast, Lung, Prostate, and Ovarian cancer (with generally poor prognosis)
Underexpressed in:Some types of gastric cancer (correlated with improved overall survival)
Scientific Papers found: Click to Expand⟱
2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, Hydrogen-gas monotherapy was started to control the tumor a month later. After 4 months, the size of multiple brain tumors was reduced significantly
OS↑, After 1 year, all brain tumors had disappeared, and there were no significant changes in metastases in the liver and lung.
Dose↝, The hydrogen oxygen nebulizer (AMS-H-03, Asclepius Meditec, Shanghai, China) generates 3 L/min hydrogen gas by hydrocephalus electrolysis. As measured by gas chromatography, the gas generated consisted of 67% hydrogen and 33% oxygen.
Dose↝, Using a special mask, the patient continued to inhale hydrogen for 3–6 hrs a day at rest, with no interruption even after the obvious relief of symptoms.
CEA↓, dropped from 29.44 to 12 ng/mL in 12 months (figure 3)
CA125↓, dropped from 150 to 60 u/mL (figure 3)
CYFRA21-1↓, dropped from 12 to 6 ng/mL (figure 3)
SIRT1↓, several scholars have demonstrated that hydrogen can suppress SIRT1 signaling in different model
COX2↓, hydrogen exerts neuroprotective effects by reducing cyclooxygenase-2 activity25 or activating expression of anti-apoptotic protein kinase B.
IL1β↓, Hydrogen inhalation can down-regulate the expression of various pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, tumor necrosis factor-α, intracellular adhesion molecule-1, high mobility group box-1, nuclear factor-kappa B, and prosta
IL6↓,
TNF-α↓,
HMGB1↓,
NF-kB↓,
EP2↓, and prostaglandin-E2

1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, 20 μmol/L TQ significantly reduced human LoVo colon cancer cell proliferation
p‑PI3K↓,
p‑Akt↓,
p‑GSK‐3β↓,
β-catenin/ZEB1↓,
COX2↓,
PGE2↓,
EP2↓,
EP4↓,

4890- ZER,    Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
- in-vitro, Nor, RAW264.7
*iNOS↓, inducible nitric oxide synthase and cyclooxygenase (COX)-2, together with the release of tumor necrosis factor-alpha, in RAW 264.7 mouse macrophages were also markedly diminished
*COX2↓,
*EP2↓, decrease in the medium concentrations of nitrite and prostaglandin E(2),
TumCP↓, ZER inhibited the proliferation of human colonic adenocarcinoma cell lines (LS174T, LS180, COLO205, and COLO320DM) in a dose-dependent manner
selectivity↑, while the growth of normal human dermal (2F0-C25) and colon (CCD-18 Co) fibroblasts was less affected.
Apoptosis↑, induced apoptosis in COLO205 cells, as detected by dysfunction of the mitochondria transmembrane,
*chemoP↑, ZER is a food phytochemical that has distinct potentials for use in anti-inflammation, chemoprevention, and chemotherapy strategies.
*Inflam↓,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

SIRT1↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP2↓, 2,   EP4↓, 1,   p‑GSK‐3β↓, 1,   p‑PI3K↓, 1,  

Migration ⓘ

CEA↓, 1,   TumCP↓, 2,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   HMGB1↓, 1,   IL1β↓, 1,   IL6↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

CA125↓, 1,   CEA↓, 1,   CYFRA21-1↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,   TumVol↓, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: EP2, Prostaglandin E2 receptor 2
1 Hydrogen Gas
1 Thymoquinone
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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