EP4 Cancer Research Results

EP4, Prostaglandin E2 receptor 4: Click to Expand ⟱
Source:
Type:
Also known as PTGER4
EP4 (Prostaglandin E2 receptor 4) - Inflammation-Driven Growth, Immune Suppression, and Metastasis
-is a receptor that plays a role in various cellular processes, including inflammation and cell growth. In cancer, EP4 has been implicated in tumor development and progression.

Overexpressed in: Colorectal, Breast, Lung, Prostate, Ovarian, GBM cancers(with poor prognosis).
Underexpressed in: Some types of renal cell carcinoma (correlated with improved overall survival).

EP4 appears to play a tumorigenic role in various types of cancer, and its expression levels can be used as a prognostic marker to predict patient outcomes.
Core Pro-Tumor Mechanisms
a. Proliferation and Survival
EP4 activation:
-Elevates cAMP/PKA and PI3K–AKT signaling
-Promotes cell survival and resistance to stress
-Cooperates with growth-factor pathways
b. Invasion and Metastasis
-EP4 enhances:
-EMT programs
-Cell migration and invasion
-Matrix remodeling and metastatic seeding
c. Angiogenesis
EP4 signaling increases:
-VEGF expression
-Endothelial migration and vessel formation
-Tumor perfusion


Scientific Papers found: Click to Expand⟱
1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, COX2↓, PGE2↓, EP2↓, EP4↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p‑Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP2↓, 1,   EP4↓, 1,   p‑GSK‐3β↓, 1,   p‑PI3K↓, 1,  

Migration ⓘ

TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   PGE2↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EP4, Prostaglandin E2 receptor 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:970  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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