MUC1-C Cancer Research Results

MUC1-C, MUC1-C: Click to Expand ⟱
Source:
Type:
MUC1-C is a truncated form of the MUC1 protein that is generated through alternative splicing.
MUC1-C lacks the extracellular domain of MUC1 and is instead localized to the cytoplasm and nucleus. MUC1-C has been shown to have distinct functions from MUC1, including the regulation of cell growth, survival, and transformation.
MUC1-C is often overexpressed in cancer cells and can contribute to oncogenesis by promoting cell proliferation, inhibiting apoptosis, and enhancing metastasis.
Scientific Papers found: Click to Expand⟱
1022- EDM,    Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis
- in-vivo, Lung, H1975 - in-vitro, Lung, H1650
TumCG↓,
Apoptosis↑,
TumCCA↑, cell cycle arrest at G2 phase
PD-L1↓,
MUC1-C↓,
TumVol↓, reduced tumor size

4911- Sal,    MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells
- in-vitro, Var, DU145
MUC1-C↓, Our results show that SAL-induced MUC1-C suppression downregulates a MUC1-C→MYC pathway
Ferroptosis↑, SAL as a unique small molecule inhibitor of MUC1-C signaling and demonstrate that MUC1-C is an important effector of resistance to ferroptosis.
CSCs↓, SAL is an effective inhibitor of CSCs
NF-kB↓, SAL suppressed MUC1-C and NF-κB expression in DU-145 and H660 cells
GSR↓, MUC1-C induces GSR expression and GSH production. We found that SAL treatment decreases GSR mRNA and protein levels
GSH↑,
Iron↑, SAL kills CSCs by sequestering iron in lysosomes and inducing ferroptosis


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GSH↑, 1,   GSR↓, 1,   Iron↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Ferroptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   TumCG↓, 1,  

Migration ⓘ

MUC1-C↓, 2,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   PD-L1↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MUC1-C, MUC1-C
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:971  State#:%  Dir#:1
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