H3K27ac Cancer Research Results

H3K27ac, histone H3 lysine 27 acetylation: Click to Expand ⟱
Source:
Type:
H3K27ac is a histone modification that is associated with active gene expression. Here are some key points about H3K27ac and its relationship to cancer:

Elevated in: breast, lung, colon, prostate ,Cancer stem cells and progenitor cells.
High levels of H3K27ac are associated with poor prognosis in:Breast,Lung,CRC cancer.
Low levels of H3K27ac are associated with good prognosis in:
Certain types of leukemia and lymphoma (correlated with increased overall survival and disease-free survival).

H3K27ac has been shown to play a role in the regulation of various oncogenes, including:
MYC
Cyclin D1
CDK4

Inhibition of H3K27ac has been shown to suppress tumor growth and induce apoptosis in various types of cancer.
Scientific Papers found: Click to Expand⟱
54- QC,    Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways
- in-vitro, BC, MCF-7
EMT↓, led to the repression of EMT promotion
E-cadherin↑,
Vim↓,
MMP2↓,
NOTCH1↓, This agent also inhibited Notch1 and PI3K/Akt signalin
PI3K/Akt↓,
PI3k/Akt/mTOR↓,
p‑Akt↓,
EZH2↓, Querectin-3-methyl ether downregulates Notch1, PI3K-AKT and EZH2 signals in breast cancer cells
H3K27ac↓, quercetin-3-methyl ether considerably decreased H3K27 methylation
TumCCA↑, cell cycle dysregulation
CSCs↓, which resulted in the downregulation of protein markers associated with cell cycle, apoptosis, stem cell pluripotency, and self-renewal, including CDK1, Cyclin B1, Bcl-xl, Bcl-2, Sox2 and Nanog
CDK1↓,
CycB/CCNB1↓,
Bcl-xL↓,
Bcl-2↓,
Nanog↓,
H3↓, Treatment with quercetin‑3‑methyl ether alone markedly suppressed the levels of tri‑methyl histone H3 (Lys27)


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   H3↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   H3K27ac↓, 1,   Nanog↓, 1,   NOTCH1↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   Vim↓, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: H3K27ac, histone H3 lysine 27 acetylation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:973  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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