ECM/TCF Cancer Research Results

ECM/TCF, Endothelial cell migration/tip cell formation: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Endothelial cell migration and tip cell formation are critical processes in angiogenesis, the formation of new blood vessels from pre-existing ones. These processes are particularly relevant in the context of cancer, where tumor growth and metastasis often depend on the development of a robust blood supply.
Tumors often secrete pro-angiogenic factors, such as VEGF, to stimulate the formation of new blood vessels. This process allows tumors to obtain the necessary nutrients and oxygen for growth and provides a route for cancer cells to enter the bloodstream and metastasize.
Many tumors overexpress VEGF to stimulate angiogenesis, allowing for increased blood supply to support tumor growth. High levels of VEGF are often associated with poor prognosis in various cancers.
Scientific Papers found: Click to Expand⟱
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓,
TumCMig↓,
MMP2↓,
MMP9↓,
ECM/TCF↓,
p‑SMAD2↓,
p‑SMAD3↓,
SMAD4↓,
p‑ERK↓,
ROS↓, reduced (TGF‐β1‐induced) intracellular ROS generation
NOX4↓,
SOD2↑,
SIRT1↑, Andro protects AECs from EMT partially by activating Sirt1/FOXO3‐mediated anti‐oxidative stress pathway
FOXO3↑,

4770- CoQ10,  VitK2,    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
- in-vitro, BC, MDA-MB-231
other↑, CoQ10 and UBIAD1 increase membrane fluidity leading to increased cell stiffness in BC
*antiOx↑, CoQ10 (or ubiquinone) is a potent lipid-soluble antioxidant enriched not only in mitochondria but also in plasma membranes
Risk↓, Loss of the CoQ10-biosynthetic enzyme UBIAD1 is associated to a worse prognosis in BC patients.
other↑, Deletion of Ubiad1 gene accelerates BC development in mouse models.
TumMeta↓, UBIAD1 expression limits metastasis formation in aggressive BC lines
ECM/TCF↓, CoQ10 and UBIAD1 expression impairs ECM-mediated signaling and AKT2 pathway in BC cells
Akt2↓,
Ferroptosis↑, UBIAD1 and CoQ10 enhance BC sensitivity to ferroptosis inducers via FSP1
eff↑, While CoQ10 treatment alone does not affect MDA-MB-231 cell viability, the co-treatment with RSL3 significantly enhanced cell death

439- CUR,    Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway
- in-vitro, CRC, LGR5
Apoptosis↑,
TumAuto↑,
GP1BB↓,
COL9A3↓,
COMP↓,
AGRN↓,
ITGB4↓,
LAMA5↓, curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.
COL2A1↓,
ITGB6↓,
LGR5↓,
TFAP2A↓,
ECM/TCF↓,

4671- CUR,    Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy
- in-vitro, CRC, NA
CSCs↓, Intriguingly, curcumin and its analogues have also recently been shown to be effective in lowering tumour recurrence by targeting the CSC population, hence inhibiting tumour growth.
TumCG↓,
ChemoSen↑, curcumin could play a role as chemosensitiser whereby the colorectal CSCs are now sensitised towards the anti-cancer therapy,
Wnt↓, Three major signaling pathways in which curcumin plays a pivotal role in CSC self-renewal behavior are the Wnt/β-catenin, Sonic Hedgehog (SHH), and Notch pathways
β-catenin/ZEB1↓,
Shh↓,
NOTCH↓,
DNMT1↓, Figure 1
STAT3↓,
NF-kB↓,
EGFR↓,
IGFR↓,
TumCCA↓,
cl‑PARP↑,
BAX↑,
ECM/TCF↓,

2918- LT,    Luteolin inhibits melanoma growth in vitro and in vivo via regulating ECM and oncogenic pathways but not ROS
- in-vitro, Melanoma, A375 - in-vivo, Melanoma, NA - in-vitro, Melanoma, SK-MEL-28
TumCG↓, Luteolin inhibited melanoma tumor growth in vitro and in vivo.
ROS↑, Luteolin induced ROS in melanoma cells but ROS was not the cause of growth inhibition.
ECM/TCF↓, luteolin inhibited ECM pathway, oncogenic pathway and modulated immune signaling.

202- MFrot,  MF,    Systematic simulation of tumor cell invasion and migration in response to time-varying rotating magnetic field
- Analysis, Var, MDA-MB-231
TumCG↓, inhibit tumor progression
MMPs↓,
ECM/TCF↓,


Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   NOX4↓, 1,   ROS↓, 1,   ROS↑, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

COMP↓, 1,   other↑, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TFAP2A↓, 1,   TumCCA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   p‑ERK↓, 1,   FOXO3↑, 1,   IGFR↓, 1,   LGR5↓, 1,   NOTCH↓, 1,   Shh↓, 1,   STAT3↓, 1,   TumCG↓, 3,   Wnt↓, 1,  

Migration ⓘ

AGRN↓, 1,   Akt2↓, 1,   COL2A1↓, 1,   COL9A3↓, 1,   GP1BB↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   LAMA5↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   SMAD4↓, 1,   TGF-β↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 6,   EGFR↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

Risk↓, 1,  
Total Targets: 51

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ECM/TCF, Endothelial cell migration/tip cell formation
2 Curcumin
1 Andrographis
1 Coenzyme Q10
1 Vitamin K2
1 Luteolin
1 Magnetic Field Rotating
1 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:99  State#:%  Dir#:1
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