Pterostilbene / miR-448 Cancer Research Results

PTS, Pterostilbene: Click to Expand ⟱

Features:

Antioxidant found in blueberries, cranberries and grapes.
Pterostilbene (trans-3,5-dimethoxy-40-hydroxystilbene) is a naturally occurring stilbene, found mainly in blueberries and grapes. It is a dimethylated derivative of resveratrol with comparable antioxidant, anti-inflammatory and anticarcinogenic properties [26].
-more bioavailable than resveratrol
-Antioxidant activity: Reduces reactive oxygen species and lipid peroxidation
-Anti-inflammatory: Downregulates pro-inflammatory cytokines- IL-1β, TNF-α, NF-κB
-Amyloid pathology:inhibits Aβ aggregation and promotes clearance- Aβ, APP, BACE1
-Reduces hyperphosphorylation of tau protein
-Inhibits histone deacetylases (HDACs)
-Increases acetylcholine by inhibiting acetylcholinesterase
-Sirtuin activation

Rank	Pathway / Axis	Cancer Cells	Normal Cells	Label	Primary Interpretation	Notes
1	SIRT1 / AMPK metabolic sensing	↑ AMPK; context-dependent SIRT1 modulation	↑ SIRT1 / ↑ AMPK	Driver	Energy-stress signaling	Pterostilbene strongly engages energy-sensing pathways due to high bioavailability
2	PI3K → AKT → mTOR axis	↓ AKT / ↓ mTOR	↔ adaptive suppression	Driver	Growth and survival inhibition	AKT/mTOR suppression explains cytostatic and pro-apoptotic effects in cancer cells
3	Reactive oxygen species (ROS)	↑ ROS (mild, dose-dependent)	↓ ROS / buffered	Conditional Driver	Biphasic redox modulation	More balanced redox profile than resveratrol; weaker pro-oxidant behavior
4	Mitochondrial integrity / intrinsic apoptosis	↓ ΔΨm; ↑ caspase activation	↔ preserved	Secondary	Execution of apoptosis	Mitochondrial apoptosis follows metabolic and redox stress
5	NF-κB signaling	↓ NF-κB activation	↓ inflammatory NF-κB tone	Secondary	Suppression of inflammatory survival programs	NF-κB inhibition contributes to anti-invasive and chemosensitizing effects
6	Cell cycle regulation	↑ G1 or G2/M arrest	↔ spared	Phenotypic	Cytostatic growth control	Cell-cycle arrest reflects upstream metabolic and signaling effects
7	NRF2 antioxidant response	↑ NRF2 (adaptive)	↑ NRF2 (protective)	Adaptive	Redox compensation	NRF2 activation contributes to stress buffering rather than primary cytotoxicity

miR-448, microRNA 448: Click to Expand ⟱

Source:

Type:

miR-448miR-448 acts as a tumor suppressor in several cancers, while in a few contexts it may act as an oncogene.
Regulation of Cancer Stemness
-Downregulates pathways that promote self-renewal and CSC maintenance (e.g., Wnt/β-catenin, PI3K/AKT)

Sensitization to Chemotherapy

Low miR-448 expression often correlates with:
-Poor overall survival
-High grade / advanced stage
-Metastasis
-Chemoresistance

Scientific Papers found: Click to Expand⟱

4698-

PTS,

Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF ‐κ B /microRNA 448 circuit

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

CSCs↓, NF-kB↓, Twist↓, Vim↓, E-cadherin↑, miR-448↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1, miR-448↑, 1,

Migration ⓘ

E-cadherin↑, 1, Twist↓, 1, Vim↓, 1,

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-448, microRNA 448

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells