Radiotherapy/Radiation / ICD Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
ICD, immunogenic cell death (ICD): Click to Expand ⟱
Source:
Type: type of cell death
Immunogenic cell death (ICD) is a form of regulated cell death that stimulates the immune system against dying cells.
ICD is characterized by the release or exposure of specific damage‐associated molecular patterns (DAMPs) that function as “danger signals.” Key DAMPs (or ICD markers) include:
• Calreticulin (CRT) exposure
• ATP release
• High mobility group box 1 protein (HMGB1) release
• Heat shock proteins (such as HSP70 and HSP90)
• Type I interferon (IFN) responses (indirectly involved through downstream signaling)

Higher expression/exposure of ICD markers such as calreticulin, ATP, extracellular HMGB1 (with favorable redox states), HSP70/90 when released, and type I IFN responses are generally associated with enhanced antitumor immunity and improved prognosis in several cancer types.
Scientific Papers found: Click to Expand⟱
5010- DSF,  Cu,  Rad,    Disulfiram/Copper Combined with Irradiation Induces Immunogenic Cell Death in Melanoma
- in-vivo, Melanoma, B16-F10
Apoptosis↑, ICD↑, HMGB1↑, ATP↓, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ICD↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling ⓘ

HMGB1↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ICD, immunogenic cell death (ICD)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:1080  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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