Radiotherapy/Radiation / SIRT6 Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱

Features:

Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.

SIRT6, Sirtuin 6: Click to Expand ⟱

Source:

Type:

– SIRT6 is involved in maintaining genomic stability through its roles in DNA repair and chromatin remodeling.
– By promoting efficient DNA repair, SIRT6 may help prevent the accumulation of genetic mutations that drive tumorigenesis.

– In several studies, lower SIRT6 expression has been associated with more aggressive tumor behavior and poorer overall survival, supporting its role as a tumor suppressor in those contexts.
– Conversely, in some cancers, higher SIRT6 expression has been linked to enhanced survival signaling or metabolic reprogramming that might support tumor growth, suggesting a possible oncogenic role.

Scientific Papers found: Click to Expand⟱

2939-

NAD,

Rad,

NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7

in-vitro,

Nor,

*SIRT6↑, *DNAdam↓, *radioP↑, *ROS↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

ROS↓, 1,

DNA Damage & Repair ⓘ

DNAdam↓, 1, SIRT6↑, 1,

Functional Outcomes ⓘ

radioP↑, 1,
Total Targets: 4

Scientific Paper Hit Count for: SIRT6, Sirtuin 6

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells