Radiotherapy/Radiation / PPP Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱

Features:

Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.

PPP, pentose phosphate pathway: Click to Expand ⟱

Source:

Type:

The pentose phosphate pathway (PPP) is a metabolic pathway that generates NADPH and pentoses from glucose-6-phosphate. In cancer, the PPP is often upregulated to support the increased demand for NADPH, which is necessary for fatty acid synthesis, antioxidant defenses, and maintaining the balance of redox reactions.

High expression of PPP enzymes is often associated with poor prognosis in various cancers, including breast, lung, colorectal, prostate, pancreatic, and ovarian cancer.

Scientific Papers found: Click to Expand⟱

5282-

3BP,

Rad,

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GSH↓, 1,

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1, GAPDH↓, 1, Glycolysis↓, 1, PPP↑, 1,

Drug Metabolism & Resistance ⓘ

eff↑, 1, RadioS↑, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PPP, pentose phosphate pathway

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells